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3-Methoxytyramine hydrochloride (CAS 1477-68-5)

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Alternate Names:
3-Methoxy-4-hydroxyphenethylamine hydrochloride; 3-MT; 4-(2-Aminoethyl)-2-methoxyphenol hydrochloride
Application:
3-Methoxytyramine hydrochloride is a major Dopamine metabolite
CAS Number:
1477-68-5
Purity:
≥95%
Molecular Weight:
203.67
Molecular Formula:
C9H13NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Methoxytyramine hydrochloride (3-OMD) emerges as a synthetic catecholamine with significant potential for scientific research applications. Derived from the endogenous catecholamine dopamine, it shares the same chemical structure as dopamine but features a methyl group attached to the 3-hydroxy position. Although the precise mechanism of action for 3-Methoxytyramine hydrochloride remains incompletely understood, it is believed to act as an agonist at dopamine receptors. By activating these receptors, it triggers a multitude of physiological responses. Specifically, 3-Methoxytyramine hydrochloride is considered a partial agonist at D1 receptors and a full agonist at D2 receptors. Additionally, it is postulated to act as an antagonist at certain serotonin receptors.


3-Methoxytyramine hydrochloride (CAS 1477-68-5) References

  1. 3-Methoxytyramine as an indicator of dopaminergic manipulation in the equine athlete.  |  Wynne, PM., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 811: 93-101. PMID: 15458727
  2. Direct injection horse-urine analysis for the quantification and confirmation of threshold substances for doping control. IV. Determination of 3-methoxytyramine by hydrophilic interaction liquid chromatography/quadrupole time-of-flight mass spectrometry.  |  Vonaparti, A., et al. 2009. Drug Test Anal. 1: 365-71. PMID: 20355216
  3. Selective extraction and determination of catecholamines in urine samples by using a dopamine magnetic molecularly imprinted polymer and capillary electrophoresis.  |  Bouri, M., et al. 2012. Talanta. 99: 897-903. PMID: 22967640
  4. Determination of catecholamines and their metabolites in rat urine by ultra-performance liquid chromatography-tandem mass spectrometry for the study of identifying potential markers for Alzheimer's disease.  |  Lv, C., et al. 2015. J Mass Spectrom. 50: 354-63. PMID: 25800017
  5. A Novel Sensitive Method to Measure Catechol-O-Methyltransferase Activity Unravels the Presence of This Activity in Extracellular Vesicles Released by Rat Hepatocytes.  |  Casal, E., et al. 2016. Front Pharmacol. 7: 501. PMID: 28066248
  6. Validation of an improved liquid chromatography tandem mass spectrometry method for rapid and simultaneous analysis of plasma catecholamine and their metabolites.  |  Yu, S., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1129: 121805. PMID: 31670057
  7. Levels of norepinephrine and dopamine in mouse brain regions following microwave inactivation--rapid post-mortem degradation of striatal dopamine in decapitated animals.  |  Blank, CL., et al. 1979. J Neurochem. 33: 213-9. PMID: 37287
  8. Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus.  |  Pardanani, JH., et al. 1977. Lloydia. 40: 585-90. PMID: 600028
  9. High-performance liquid chromatography with electrochemical detection for the simultaneous determination of the methoxylated amines, normetanephrine, metanephrine and 3-methoxytyramine, in urine.  |  Jouve, J., et al. 1983. J Chromatogr. 274: 53-62. PMID: 6874854
  10. Palladium(II) Complexes with Catecholamines: Synthesis and In Vitro Cytotoxic Activity  |  , et al. (2021). Russian Journal of General Chemistry. volume 91,: pages 1354–1360.
  11. Preparation of deuterium labelled catecholamines  |   and Lakshmi D. Saraswat, Janis M. Kenny, Sharon K. Davis, Joseph B. Justice. October 1981. Journal of Labelled Compounds and Radiopharmaceuticals. Volume18, Issue10: Pages 1507-1516.
  12. Development of a sensitive and fast method for detection of catecholamines and metabolites by HRMS  |  RR Roiffé, WD Ribeiro, VF Sardela, MNS de la Cruz… - Microchemical …, 2019 - Elsevier. November 2019,. Microchemical Journal. Volume 150,: 104173.
  13. Structural and spectral analysis of 3-metoxytyramine, an important metabolite of dopamine  |  D Dimić, D Milenković, Z Marković… - Journal of Molecular …, 2017 - Elsevier. 15 April 2017. Journal of Molecular Structure. Volume 1134,,: Pages 226-236.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Methoxytyramine hydrochloride, 100 mg

sc-254500
100 mg
$64.00

Dear Sirs, Do you have from this material 2 x 100 mg on stock ? When can we expect the delivery ? After your remind we will send you an order. Best regards, Bernhard Marx (Buyer) Bio-Rad Laboratories GmbH 80939 München Germany

Asked by: Bio Rad Laboratories GmbH
Thank you for your question. The product is currently in stock. We offer over night shipment to many locations. Please contact our Customer Service department to place a product order or to ask for a sales quotation inlcuding delivery time.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-26
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Rated 5 out of 5 by from 33,4-dihydroxyphenylacetic acid was utilized in many articles as a dopamine metabolite. -SCBT Publication Review
Date published: 2015-07-02
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3-Methoxytyramine hydrochloride is rated 5.0 out of 5 by 1.
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