Molecular structure of 3-MATIDA, CAS Number: 518357-51-2
3-MATIDA (CAS 518357-51-2)
Application:
3-MATIDA is a potent mGluR-1 antagonist
CAS Number:
518357-51-2
Purity:
≥97%
Molecular Weight:
215.23 (anhydrous)
Molecular Formula:
C8H9NO4S•xH20
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-MATIDA is a potent metabotropic glutamate receptor 1(mGluR-1) antagonist (IC50 = 6.3 muM at rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 muM), NMDA and GluR (AMPA) (IC50 = 250 muM). 3-MATIDA has been found to act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.
3-MATIDA (CAS 518357-51-2) References
- The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. | Moroni, F., et al. 2002. Neuropharmacology. 42: 741-51. PMID: 12015200
- Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? | Cozzi, A., et al. 2002. Neuropharmacology. 43: 119-30. PMID: 12213266
- Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures. | Meli, E., et al. 2005. Neuropharmacology. 49 Suppl 1: 80-8. PMID: 16023154
- Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons. | Bonsi, P., et al. 2007. Eur J Neurosci. 25: 1319-31. PMID: 17425558
- Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of ischemic tolerance. | Werner, CG., et al. 2007. Eur J Neurosci. 25: 3597-604. PMID: 17610579
- Depolarization-induced slow current in cerebellar Purkinje cells does not require metabotropic glutamate receptor 1. | Shin, JH., et al. 2009. Neuroscience. 162: 688-93. PMID: 19409231
- Non-competitive metabotropic glutamate 1 receptor antagonists block activity of slowly adapting type I mechanoreceptor units in the rat sinus hair follicle. | Cahusac, PM. and Mavulati, SC. 2009. Neuroscience. 163: 933-41. PMID: 19596050
- Gray matter NG2 cells display multiple Ca2+-signaling pathways and highly motile processes. | Haberlandt, C., et al. 2011. PLoS One. 6: e17575. PMID: 21455301
- Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents. | Zheng, N. and Raman, IM. 2011. J Neurosci. 31: 10283-92. PMID: 21753005
- Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5. | Sevastyanova, TN. and Kammermeier, PJ. 2014. Mol Pharmacol. 86: 492-504. PMID: 25113912
- Metabotropic glutamate receptor 5 upregulates surface NMDA receptor expression in striatal neurons via CaMKII. | Jin, DZ., et al. 2015. Brain Res. 1624: 414-423. PMID: 26256252
- AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting. | Laing, BT., et al. 2018. Front Cell Neurosci. 12: 276. PMID: 30233321
- Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks. | Djemil, S., et al. 2020. J Neurochem. 153: 468-484. PMID: 31821553
Inhibitor of:
GluR, mGluR-1a, and NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-MATIDA, 10 mg | sc-203470 | 10 mg | $566.00 | |||
3-MATIDA, 25 mg | sc-203470A | 25 mg | $1081.00 |