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3-MATIDA is a potent metabotropic glutamate receptor 1(mGluR-1) antagonist (IC50 = 6.3 μM at rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA has been found to act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.
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