Molecular structure of 3-Maleimido-PROXYL, CAS Number: 5389-27-5
3-Maleimido-PROXYL (CAS 5389-27-5)
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Alternate Names:
3-Maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxy, free radical
Application:
3-Maleimido-PROXYL is a spin label used for study of local protein and membrane structure
CAS Number:
5389-27-5
Molecular Weight:
237.28
Molecular Formula:
C12H17N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Maleimido-PROXYL, also known as MTEMPO or 3-Maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxy, is a stable nitroxide radical extensively utilized in scientific research. Its distinctive structure enables it to function as a spin label in diverse experimental scenarios. The synthesis of 3-Maleimido-PROXYL involves the reaction between maleimide and 2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid. By attaching to a specific location on a molecule and modifying its electron spin, 3-Maleimido-PROXYL acts as a spin label. This alteration in spin can be detected using EPR spectroscopy, facilitating the investigation of the molecule′s structure and dynamics by researchers.
3-Maleimido-PROXYL (CAS 5389-27-5) References
- Protein dynamics in thylakoids of the desiccation-tolerant plant Boea hygroscopica during dehydration and rehydration. | Navari-Izzo, F., et al. 2000. Plant Physiol. 124: 1427-36. PMID: 11080317
- Configurations of the N-terminal amphipathic domain of the membrane-bound M13 major coat protein. | Meijer, AB., et al. 2001. Biochemistry. 40: 5081-6. PMID: 11305925
- Analysis of side chain rotational restrictions of membrane-embedded proteins by spin-label ESR spectroscopy. | Strancar, J., et al. 2009. J Magn Reson. 197: 245-8. PMID: 19138542
- Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C. | Leferink, NG., et al. 2009. Plant Physiol. 150: 596-605. PMID: 19369590
- Distance determination in proteins inside Xenopus laevis oocytes by double electron-electron resonance experiments. | Igarashi, R., et al. 2010. J Am Chem Soc. 132: 8228-9. PMID: 20513154
- Identification of different classes of nonessential sulfhydryl groups in Escherichia coli adenylosuccinate synthetase. | Dong, Q., et al. 1990. Arch Biochem Biophys. 276: 77-84. PMID: 2153366
- Introduction to spin label electron paramagnetic resonance spectroscopy of proteins. | Melanson, M., et al. 2013. Biochem Mol Biol Educ. 41: 156-62. PMID: 23281241
- EPR and NMR spectroscopies provide input on the coordination of Cu(I) and Ag(I) to a disordered methionine segment. | Shenberger, Y., et al. 2015. J Biol Inorg Chem. 20: 719-27. PMID: 25822808
- Room-temperature in-cell EPR spectroscopy: alpha-Synuclein disease variants remain intrinsically disordered in the cell. | Cattani, J., et al. 2017. Phys Chem Chem Phys. 19: 18147-18151. PMID: 28696461
- Maleimido-proxyl as an EPR spin label for the evaluation of conformational changes of albumin. | Pavićević, A., et al. 2017. Eur Biophys J. 46: 773-787. PMID: 28942583
- Direct Application of 3-Maleimido-PROXYL for Proving Hypoalbuminemia in Cases of SARS-CoV-2 Infection: The Potential Diagnostic Method of Determining Albumin Instability and Oxidized Protein Level in Severe COVID-19. | Georgieva, E., et al. 2023. Int J Mol Sci. 24: PMID: 36982882
- Pharmacokinetic analysis of free radicals by in vivo BCM (Blood Circulation Monitoring)-ESR method. | Takechi, K., et al. 1997. Free Radic Res. 26: 483-96. PMID: 9212342
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Maleimido-PROXYL, 25 mg | sc-252019 | 25 mg | $259.00 |