Date published: 2026-4-19

1-800-457-3801

SCBT Portrait Logo
Seach Input

3-Keto Valproic Acid Sodium Salt (CAS 1184991-15-8)

0.0(0)
Write a reviewAsk a question

Alternate Names:
3-keto-VPA; 3-oxo-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-3-oxopentanoic Acid Sodium Salt;
Application:
3-Keto Valproic Acid Sodium Salt is a useful main metabolite of Valproic Acid
CAS Number:
1184991-15-8
Purity:
≥95%
Molecular Weight:
180.18
Molecular Formula:
C8H13NaO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

3-Keto Valproic Acid Sodium Salt is a derivative of valproic acid. In biochemistry, 3-Keto Valproic Acid Sodium Salt inhibits histone deacetylase (HDAC) enzymes, which play a role in gene expression and cell differentiation. This inhibition can lead to changes in the expression of various genes, impacting cellular processes such as apoptosis, cell cycle regulation, and DNA repair. Its mechanism of action in modulating gene expression and cellular processes makes it understanding epigenetic regulation and its implications in various biological pathways.


3-Keto Valproic Acid Sodium Salt (CAS 1184991-15-8) References

  1. Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.  |  Kumar, S., et al. 2000. Drug Metab Dispos. 28: 857-64. PMID: 10859160
  2. Do structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis.  |  Bello-Ramírez, AM., et al. 2002. Epilepsia. 43: 475-81. PMID: 12027907
  3. Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations.  |  Bjorge, SM. and Baillie, TA. 1991. Drug Metab Dispos. 19: 823-9. PMID: 1680661
  4. Metabolic profiling of valproic acid in patients using negative-ion chemical ionization gas chromatography-mass spectrometry.  |  Kassahun, K., et al. 1990. J Chromatogr. 527: 327-41. PMID: 2117614
  5. Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice.  |  Avery, LB. and Bumpus, NN. 2014. Mol Pharmacol. 85: 1-10. PMID: 24105977
  6. Development of human liver UDP-glucuronosyltransferases.  |  Burchell, B., et al. 1989. Dev Pharmacol Ther. 13: 70-7. PMID: 2515047
  7. Effects of Carnitine on Valproic Acid Pharmacokinetics in Rats.  |  Katayama, H., et al. 2016. J Pharm Sci. 105: 3199-3204. PMID: 27499337
  8. Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning.  |  Jawień, W., et al. 2017. Pharmacol Rep. 69: 340-349. PMID: 28187395
  9. Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.  |  Yang, X., et al. 2023. Biomed Chromatogr. 37: e5572. PMID: 36520520
  10. Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate.  |  Heinemeyer, G., et al. 1985. Biochem Pharmacol. 34: 133-9. PMID: 3917666
  11. Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings.  |  Löscher, W., et al. 1981. Neuropharmacology. 20: 1187-92. PMID: 6798485
  12. Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice.  |  Löscher, W. and Nau, H. 1982. Arch Int Pharmacodyn Ther. 257: 20-31. PMID: 6810778
  13. Plasma levels of valproic acid and its metabolites during continued treatment in dogs.  |  Löscher, W. 1981. J Vet Pharmacol Ther. 4: 111-9. PMID: 6818360
  14. Decreased serum carnitine in valproate induced Reye syndrome.  |  Böhles, H., et al. 1982. Eur J Pediatr. 139: 185-6. PMID: 6819143
  15. CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid.  |  Rettie, AE., et al. 1995. Biochemistry. 34: 7889-95. PMID: 7794900

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Keto Valproic Acid Sodium Salt, 25 mg

sc-216476B
25 mg
$224.00

3-Keto Valproic Acid Sodium Salt, 100 mg

sc-216476
100 mg
$408.00

3-Keto Valproic Acid Sodium Salt, 500 mg

sc-216476A
500 mg
$1290.00

3-Keto Valproic Acid Sodium Salt, 1 g

sc-216476C
1 g
$2244.00