Molecular structure of 3-Iodothyroacetic Acid
3-Iodothyroacetic Acid (CAS 60578-17-8)
Alternate Names:
4-(4-Hydroxyphenoxy)-3-iodobenzeneacetic Acid; [4-(p-Hydroxyphenoxy)-3-iodophenyl]acetic Acid
CAS Number:
60578-17-8
Molecular Weight:
370.14
Molecular Formula:
C14H11IO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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3-Iodothyroacetic Acid is a chemical compound that belongs to the class of thyroid hormones. It is derived from thyroacetic acid by the addition of an iodine atom at the 3-position. 3-Iodothyronacetic Acid is a 3-Iodothyronamine metabolite may act to produce behavioral effects in mice that are dependent on brain histamine.
3-Iodothyroacetic Acid (CAS 60578-17-8) References
- Tissue distribution and cardiac metabolism of 3-iodothyronamine. | Saba, A., et al. 2010. Endocrinology. 151: 5063-73. PMID: 20739399
- Uptake and metabolic effects of 3-iodothyronamine in hepatocytes. | Ghelardoni, S., et al. 2014. J Endocrinol. 221: 101-10. PMID: 24627446
- Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism. | Musilli, C., et al. 2014. Br J Pharmacol. 171: 3476-84. PMID: 24641572
- 3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice. | Laurino, A., et al. 2015. Br J Pharmacol. 172: 1859-68. PMID: 25439265
- In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine. | Laurino, A., et al. 2015. Eur J Pharmacol. 761: 130-4. PMID: 25941083
- 3-Iodothyroacetic acid (TA1), a by-product of thyroid hormone metabolism, reduces the hypnotic effect of ethanol without interacting at GABA-A receptors. | Laurino, A., et al. 2018. Neurochem Int. 115: 31-36. PMID: 29032008
- Anticonvulsant and Neuroprotective Effects of the Thyroid Hormone Metabolite 3-Iodothyroacetic Acid. | Laurino, A., et al. 2018. Thyroid. 28: 1387-1397. PMID: 30129879
- N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity. | Landucci, E., et al. 2019. Neurochem Int. 129: 104460. PMID: 31075293
- Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1). | Laurino, A., et al. 2019. Front Cell Neurosci. 13: 176. PMID: 31133807
- Exogenous 3-Iodothyronamine Rescues the Entorhinal Cortex from β-Amyloid Toxicity. | Accorroni, A., et al. 2020. Thyroid. 30: 147-160. PMID: 31709926
- Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study. | di Leo, N., et al. 2021. Molecules. 26: PMID: 33799468
- Redox Properties of 3-Iodothyronamine (T1AM) and 3-Iodothyroacetic Acid (TA1). | Gencarelli, M., et al. 2022. Int J Mol Sci. 23: PMID: 35269859
- Exogenous 3-Iodothyronamine (T1AM) Can Affect Phosphorylation of Proteins Involved on Signal Transduction Pathways in In Vitro Models of Brain Cell Lines, but These Effects Are Not Strengthened by Its Catabolite, 3-Iodothyroacetic Acid (TA1). | Bandini, L., et al. 2022. Life (Basel). 12: PMID: 36143389
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Iodothyroacetic Acid, 10 mg | sc-488513 | 10 mg | $400.00 |