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3-Iodo-L-thyronine (CAS 10468-90-3)

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Alternate Names:
O-(4-Hydroxyphenyl)-3-iodo-L-tyrosine; 3-Monoiodothyronine
Application:
3-Iodo-L-thyronine is a metabolite of thyroid hormone
CAS Number:
10468-90-3
Molecular Weight:
399.18
Molecular Formula:
C15H14INO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Iodo-L-thyronine functions as a thyroid hormone analog in experimental applications. It interacts with thyroid hormone receptors in cells, modulating gene expression and influencing cellular metabolism. 3-Iodo-L-Thyronine has a specific mechanism of action, binding to thyroid hormone receptors and affecting the transcription of target genes. By doing so, it can regulate various physiological processes at the molecular level, such as metabolism, growth, and development. 3-Iodo-L-thyronine can be used to study the molecular mechanisms of thyroid hormone action and its impact on cellular function. Its mechanism of action involves influencing the expression of specific genes, providing insights into the role of thyroid hormones in cellular processes.


3-Iodo-L-thyronine (CAS 10468-90-3) References

  1. A method for the analysis of six thyroid hormones in thyroid gland by liquid chromatography-tandem mass spectrometry.  |  Kunisue, T., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 1725-30. PMID: 20466602
  2. Determination of six thyroid hormones in the brain and thyroid gland using isotope-dilution liquid chromatography/tandem mass spectrometry.  |  Kunisue, T., et al. 2011. Anal Chem. 83: 417-24. PMID: 21121614
  3. Modulation of thyroid hormone concentrations in serum of rats coadministered with perchlorate and iodide-deficient diet.  |  Kunisue, T., et al. 2011. Arch Environ Contam Toxicol. 61: 151-8. PMID: 21573761
  4. Analysis of thyroid hormones in serum of Baikal seals and humans by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassay methods: application of the LC-MS/MS method to wildlife tissues.  |  Kunisue, T., et al. 2011. Environ Sci Technol. 45: 10140-7. PMID: 22035339
  5. ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation.  |  Roy, G., et al. 2012. J Biol Chem. 287: 1790-800. PMID: 22128163
  6. Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2.  |  Hinz, KM., et al. 2015. Mol Endocrinol. 29: 933-42. PMID: 25945809
  7. A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes.  |  Richards, KH., et al. 2017. PLoS One. 12: e0183482. PMID: 28837607
  8. Determination of free thyroid hormones in animal serum/plasma using ultrafiltration in combination with ultra-fast liquid chromatography-tandem mass spectrometry.  |  Tanoue, R., et al. 2018. J Chromatogr A. 1539: 30-40. PMID: 29395158
  9. Persistent Organic Pollutants in Human Breast Milk and Associations with Maternal Thyroid Hormone Homeostasis.  |  Li, ZM., et al. 2020. Environ Sci Technol. 54: 1111-1119. PMID: 31867966
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  13. Synthesis of 3-iodo-L-thyronine and its iodinated derivatives.  |  Block, P. 1976. J Med Chem. 19: 1067-9. PMID: 966253

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Iodo-L-thyronine, 50 mg

sc-209623
50 mg
$339.00