Date published: 2026-4-28

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3-Hydroxypyridine (CAS 109-00-2)

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Alternate Names:
3-Pyridinol; 3-Pyridone
CAS Number:
109-00-2
Molecular Weight:
95.10
Molecular Formula:
C5H5NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Hydroxypyridine is a pale yellow solid, soluble in water and alcohol but not in organic solvents. As a weak base, it can combine with acids to produce salts. This compound is involved in multiple chemical reactions including esterification, oxidation, and halogenation. The reactions have been thoroughly studied in model systems. Furthermore, 3-Hydroxypyridine can engage with hydroxyl groups on other molecules either through hydrogen bonding or by creating intramolecular hydrogen bonds.


3-Hydroxypyridine (CAS 109-00-2) References

  1. Caging and solvent effects on the tautomeric equilibrium of 3-pyridone/3-hydroxypyridine in the ground state: a study in cyclodextrins and binary solvents.  |  Abou-Zied, OK. and Al-Shihi, OI. 2009. Phys Chem Chem Phys. 11: 5377-83. PMID: 19551205
  2. Energotropic effect of succinate-containing derivatives of 3-hydroxypyridine.  |  Lukyanova, LD., et al. 2009. Bull Exp Biol Med. 148: 587-91. PMID: 20396747
  3. [Investigation of anti-hypoxic action of 3-hydroxypyridine derivatives in animals with some types of experimental pathology].  |  Iasnetsov, VV., et al. 2010. Aviakosm Ekolog Med. 44: 57-60. PMID: 21033401
  4. [Antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives and their nootropic action in alloxan diabetes].  |  Volchegorskiĭ, IA., et al. 2011. Eksp Klin Farmakol. 74: 27-32. PMID: 22379879
  5. Copper(II) bis(4,4,4-trifluoro-1-phenylbutane-1,3-dionate) complexes with pyridin-2-one, 3-hydroxypyridine and 3-hydroxypyridin-2-one ligands: molecular structures and hydrogen-bonded networks.  |  Perdih, F. 2017. Acta Crystallogr C Struct Chem. 73: 960-967. PMID: 29111526
  6. Isolation of a 3-hydroxypyridine degrading bacterium, Agrobacterium sp. DW-1, and its proposed degradation pathway.  |  Zhao, S., et al. 2019. AMB Express. 9: 65. PMID: 31102032
  7. 3-Hydroxypyridine Dehydrogenase HpdA Is Encoded by a Novel Four-Component Gene Cluster and Catalyzes the First Step of 3-Hydroxypyridine Catabolism in Ensifer adhaerens HP1.  |  Wang, H., et al. 2020. Appl Environ Microbiol. 86: PMID: 32709720
  8. Reversible Redox System of 2-Oxypyritriphyrin(1.2.1) Accompanying Interconversion between 3-Pyridone and 3-Hydroxypyridine Units.  |  Chong, SG., et al. 2021. Chem Asian J. 16: 1077-1080. PMID: 33713547
  9. Fenton's reagent-enhanced supercritical water oxidation of wastewater released from 3-hydroxypyridine production.  |  Bu, J., et al. 2019. RSC Adv. 9: 29317-29326. PMID: 35528409
  10. Chemical kinetics and promoted Co-immobilization for efficient catalytic carbonylation of ethylene oxide into methyl 3-hydroxypropionate.  |  Luo, J., et al. 2022. Front Chem. 10: 945028. PMID: 35936085
  11. Aryloxy Ionic Liquid-Catalyzed Homogenous Esterification of Cellulose with Low-Reactive Acyl Donors.  |  Yoshizawa, A., et al. 2023. Polymers (Basel). 15: PMID: 36679299
  12. The effects of chronic unpredicted mild stress on maternal negative emotions and gut microbiota and metabolites in pregnant rats.  |  Wang, R., et al. 2023. PeerJ. 11: e15113. PMID: 37090110
  13. Untargeted GC-MS and FT-NIR study of the effect of 14 processing methods on the volatile components of Polygonatum kingianum.  |  Xu, Y., et al. 2023. Front Plant Sci. 14: 1140691. PMID: 37223798

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Hydroxypyridine, 25 g

sc-223545
25 g
$29.00

3-Hydroxypyridine, 100 g

sc-223545A
100 g
$50.00