Molecular structure of 3-Hydroxyglutaric Acid, CAS Number: 638-18-6
3-Hydroxyglutaric Acid (CAS 638-18-6)
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Alternate Names:
3-Hydroxyglutaric Acid is also known as 3-HG.
Application:
3-Hydroxyglutaric Acid is a glutaric acid derivative and byproduct of Glutaric acidemia type I, used as a marker for GCDH deficiency.
CAS Number:
638-18-6
Molecular Weight:
148.11
Molecular Formula:
C5H8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Hydroxyglutaric Acid is primarily used in research that focuses on metabolic pathways involved in organic acid metabolism. This compound is instrumental in studying disorders of the tricarboxylic acid cycle and related metabolic disturbances. Research involving 3-Hydroxyglutaric Acid typically investigates its accumulation and excretion in conditions affecting metabolic processes, providing insights into biochemical pathways and potential disruptions. Additionally, it is utilized in studies aiming to understand the enzyme kinetics associated with its production and degradation. Furthermore, 3-Hydroxyglutaric Acid serves as a tool in metabolic engineering, where it is used to explore new ways of biologically synthesizing chemicals that are environmentally sustainable and economically beneficial.
3-Hydroxyglutaric Acid (CAS 638-18-6) References
- 3-Hydroxyglutaric and glutaric acids are neurotoxic through NMDA receptors in vitro. | Kölker, S., et al. 1999. J Inherit Metab Dis. 22: 259-62. PMID: 10384382
- Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. | Kölker, S., et al. 2000. Pediatr Res. 47: 495-503. PMID: 10759157
- IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures. | Bjugstad, KB., et al. 2001. J Inherit Metab Dis. 24: 631-47. PMID: 11768583
- 3-Hydroxyglutarate excretion is increased in ketotic patients: implications for glutaryl-CoA dehydrogenase deficiency testing. | Pitt, J., et al. 2002. J Inherit Metab Dis. 25: 83-8. PMID: 12118531
- Quantification of 3-hydroxyglutaric acid in urine, plasma, cerebrospinal fluid and amniotic fluid by stable-isotope dilution negative chemical ionization gas chromatography-mass spectrometry. | Schor, DS., et al. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 780: 199-204. PMID: 12383496
- 3-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats. | Frizzo, ME., et al. 2004. Neurochem Int. 44: 345-53. PMID: 14643752
- 3-Hydroxyglutaric acid fails to affect the viability of primary neuronal rat cells. | Freudenberg, F., et al. 2004. Neurobiol Dis. 16: 581-4. PMID: 15262270
- Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats. | Rosa, RB., et al. 2004. Neurochem Int. 45: 1087-94. PMID: 15337308
- Promotion of oxidative stress by 3-hydroxyglutaric acid in rat striatum. | Latini, A., et al. 2005. J Inherit Metab Dis. 28: 57-67. PMID: 15702406
- 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3. | Stellmer, F., et al. 2007. J Mol Med (Berl). 85: 763-70. PMID: 17356845
- Evidence for a synergistic action of glutaric and 3-hydroxyglutaric acids disturbing rat brain energy metabolism. | Ferreira, GC., et al. 2007. Int J Dev Neurosci. 25: 391-8. PMID: 17643899
- Quantitation of plasma and urine 3-hydroxyglutaric acid, after separation from 2-hydroxyglutaric acid and other compounds of similar ion transition, by liquid chromatography-tandem mass spectrometry for the confirmation of glutaric aciduria type 1. | Simon, GA. and Wierenga, A. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1097-1098: 101-110. PMID: 30218917
- Formation of 3-hydroxyglutaric acid in glutaric aciduria type I: in vitro participation of medium chain acyl-CoA dehydrogenase. | Peters, V., et al. 2019. JIMD Rep. 47: 30-34. PMID: 31240164
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Hydroxyglutaric Acid, 5 mg | sc-209609A | 5 mg | $200.00 | |||
3-Hydroxyglutaric Acid, 10 mg | sc-209609 | 10 mg | $240.00 | |||
3-Hydroxyglutaric Acid, 25 mg | sc-209609B | 25 mg | $600.00 | |||
3-Hydroxyglutaric Acid, 50 mg | sc-209609C | 50 mg | $1000.00 | |||
3-Hydroxyglutaric Acid, 100 mg | sc-209609D | 100 mg | $2423.00 |