3-Hydroxy Valproic Acid (CAS 58888-84-9)

3-Hydroxy Valproic Acid is a metabolite of Valproic Acid. Notably, numerous studies have demonstrated the anti-tumor potential of 3-Hydroxyvalproic acid, as it can induce apoptosis in cancer cells. Furthermore, it exhibits neuroprotective properties, enhancing cognitive function in animal models of Alzheimer′s disease and Parkinson′s disease. Additionally, 3-Hydroxyvalproic acid has shown promising effects in regulating glucose and lipid metabolism. The metabolism of Valproic Acid to 3-Hydroxy Valproic Acid has been observed to occur after incubation of Valproic Acid with rat liver microsomes. This conversion is thought to occur in vivo as a product of fatty acid hydroxylation. The parent compound, Valproic Acid, is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase. Metabolites of Valproic Acid are also available as: Valproic Acid (sc-213144) Valproic Acid, Sodium Salt (sc-202378) 3-Keto Valproic Acid Sodium Salt (sc-216476) 4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870) rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266) Valproic Acid beta-D-Glucuronide Allyl Ester (sc-220360) Valproic Acid beta-D-Glucuronide (sc-213145) Labelled forms of Valproic Acid are available as: Valproic Acid-d6 (sc-213146) Valproic Acid-d6 beta-D-Glucuronide (sc-220361) rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)