Molecular structure of 3-Hydroxy-DL-kynurenine, CAS Number: 2147-61-7
3-Hydroxy-DL-kynurenine (CAS 2147-61-7)
See product citations (3)
Alternate Names:
α,2-Diamino-3-hydroxy-γ-oxobenzenebutanoic acid
Application:
3-Hydroxy-DL-kynurenine is a tryptophan metabolite
CAS Number:
2147-61-7
Purity:
≥98%
Molecular Weight:
224.21
Molecular Formula:
C10H12N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Hydroxy-DL-kynurenine is a tryptophan metabolite that is a chromophore present in the lens of the eye. Within the field of neurobiology, 3-Hydroxy-DL-kynurenine has demonstrated its ability to influence the activity of the N-methyl-D-aspartate (NMDA) receptor, a component involved in fundamental processes like learning, memory, and synaptic plasticity. In the realm of immunology, 3-Hydroxy-DL-kynurenine has exhibited its capacity to regulate the functioning of immune cells, particularly T cells and macrophages. Furthermore, within the domain of cancer research, 3-Hydroxy-DL-kynurenine has shown promising anti-tumor properties.
3-Hydroxy-DL-kynurenine (CAS 2147-61-7) References
- Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase. | Han, Q., et al. 2001. Biochem J. 360: 617-23. PMID: 11736651
- Kynurenine pyruvate transaminase and its specific inhibitor in rat intestine. | Kido, R. and Noguchi, T. 1975. Acta Vitaminol Enzymol. 29: 310-2. PMID: 1244114
- Crystal structure of Homo sapiens kynureninase. | Lima, S., et al. 2007. Biochemistry. 46: 2735-44. PMID: 17300176
- Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway. | Narui, K., et al. 2009. Biol Pharm Bull. 32: 41-4. PMID: 19122278
- Effects of kynurenine metabolites on mesangial cell proliferation and gene expression. | Yoshimura, H., et al. 2009. Exp Mol Pathol. 87: 70-5. PMID: 19268458
- Positive selection of a duplicated UV-sensitive visual pigment coincides with wing pigment evolution in Heliconius butterflies. | Briscoe, AD., et al. 2010. Proc Natl Acad Sci U S A. 107: 3628-33. PMID: 20133601
- UV photoreceptors and UV-yellow wing pigments in Heliconius butterflies allow a color signal to serve both mimicry and intraspecific communication. | Bybee, SM., et al. 2012. Am Nat. 179: 38-51. PMID: 22173459
- Human plasma lipofuscin melanins formed from tryptophan metabolites. | Hegedus, ZL., et al. 1986. Arch Int Physiol Biochim. 94: 339-48. PMID: 2440410
- Actinomycin synthesis in Streptomyces antibioticus: enzymatic conversion of 3-hydroxyanthranilic acid to 4-methyl-3-hydroxyanthranilic acid. | Jones, GH. 1987. J Bacteriol. 169: 5575-8. PMID: 2445729
- Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3. | Thomas, ML., et al. 2016. Mol Oncol. 10: 1485-1496. PMID: 27592281
- Ultraviolet and yellow reflectance but not fluorescence is important for visual discrimination of conspecifics by Heliconius erato. | Finkbeiner, SD., et al. 2017. J Exp Biol. 220: 1267-1276. PMID: 28108668
- HPLC Gradient Retention of Tryptophan and its Metabolites on Three Stationary Phases in Context of Lipophilicity Assessment. | Wicha-Komsta, K., et al. 2021. J Chromatogr Sci. 59: 40-46. PMID: 33107556
- The influence of tryptophan and its metabolites upon rabbit lens electrolyte balance. | Kishida, K., et al. Curr Eye Res. 2: 309-15. PMID: 6219861
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Hydroxy-DL-kynurenine, 25 mg | sc-214132 | 25 mg | $184.00 | |||
3-Hydroxy-DL-kynurenine, 100 mg | sc-214132A | 100 mg | $490.00 | |||
3-Hydroxy-DL-kynurenine, 250 mg | sc-214132B | 250 mg | $1050.00 |