Molecular structure of 3-Hydroxy Anagrelide, CAS Number: 733043-41-9
3-Hydroxy Anagrelide (CAS 733043-41-9)
Alternate Names:
6,7-Dichloro-1,5-dihydro-3-hydroxyimidazo[2,1-b]quinazolin-2(3H)-one
CAS Number:
733043-41-9
Molecular Weight:
272.09
Molecular Formula:
C10H7Cl2N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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The compound 3-Hydroxy Anagrelide effectively hinders the clumping of platelets by selectively inhibiting platelet aggregation. Its mechanism of action involves targeting phosphodiesterase III, thereby causing a decline in cyclic AMP (cAMP) levels within cells. This decrease in cAMP levels leads to a significant decrease in platelet aggregation and a subsequent reduction in platelet count.
3-Hydroxy Anagrelide (CAS 733043-41-9) References
- A potent new inhibitor of platelet aggregation and experimental thrombosis, anagrelide (BL-4162A). | Fleming, JS. and Buyniski, JP. 1979. Thromb Res. 15: 373-88. PMID: 115106
- Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. | Mazur, EM., et al. 1992. Blood. 79: 1931-7. PMID: 1562721
- Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. | Wang, G., et al. 2005. Br J Pharmacol. 146: 324-32. PMID: 16041400
- Anagrelide: a review of its use in the management of essential thrombocythaemia. | Wagstaff, AJ. and Keating, GM. 2006. Drugs. 66: 111-31. PMID: 16398570
- Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. | Gillespie, E. 1988. Biochem Pharmacol. 37: 2866-8. PMID: 2456068
- Pharmacokinetics of a Novel Anagrelide Extended-Release Formulation in Healthy Subjects: Food Intake and Comparison With a Reference Product. | Petrides, PE., et al. 2018. Clin Pharmacol Drug Dev. 7: 123-131. PMID: 28301098
- Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations. | Takei, H., et al. 2018. Br J Haematol. 181: 791-802. PMID: 29741776
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Hydroxy Anagrelide, 5 mg | sc-206647 | 5 mg | $444.00 |