Date published: 2026-4-5

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3-Hydroxy-4-nitrobenzoic acid (CAS 619-14-7)

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CAS Number:
619-14-7
Molecular Weight:
183.12
Molecular Formula:
C7H5NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Hydroxy-4-nitrobenzoic acid plays a role in synthetic organic chemistry, serving as a vital reagent for the synthesis of various compounds. In the field of biochemistry, it demonstrates significance as an inhibitor of enzymes implicated in drug metabolism. Through binding to the active sites of these enzymes, it obstructs their interaction with drugs, effectively impeding their metabolism. This distinctive mechanism positions 3-Hydroxy-4-nitrobenzoic acid as a valuable asset in research endeavors exploring drug metabolism, facilitating a deeper understanding of this intricate process.


3-Hydroxy-4-nitrobenzoic acid (CAS 619-14-7) References

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  2. Selective detection of 2-nitrobenzenesulfenyl-labeled peptides by matrix-assisted laser desorption/ionization-time of flight mass spectrometry using a novel matrix.  |  Matsuo, E., et al. 2006. Proteomics. 6: 2042-9. PMID: 16521152
  3. Isolation and identification of new vasodilative substances in diesel exhaust particles.  |  Seki, K., et al. 2010. Environ Sci Pollut Res Int. 17: 717-23. PMID: 19557451
  4. Glycine conjugation of the substituted benzoic acids in vitro: structure-metabolism relationship study.  |  Kasuya, F., et al. 1990. J Pharmacobiodyn. 13: 432-40. PMID: 2290127
  5. 3-Hydroxy-4-nitrobenzoic Acid as a MALDI Matrix for In-Source Decay.  |  Fukuyama, Y., et al. 2016. Anal Chem. 88: 8058-63. PMID: 27467192
  6. Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2.  |  Cheng, B., et al. 2017. Angew Chem Int Ed Engl. 56: 12755-12759. PMID: 28731542
  7. 3-Hydroxy-2-Nitrobenzoic Acid as a MALDI Matrix for In-Source Decay and Evaluation of the Isomers.  |  Fukuyama, Y., et al. 2018. J Am Soc Mass Spectrom. 29: 2227-2236. PMID: 30062476
  8. Rapid evaluation of the substrate specificity of 3-nitrobenzoic acid dioxygenase MnbAB via colorimetric detection using Saltzman reagent.  |  Tomita, H., et al. 2021. J Ind Microbiol Biotechnol. 48: PMID: 34453549
  9. Selective removal of uranyl ions using ion-imprinted amino-phenolic functionalized chitosan.  |  Elsayed, NH., et al. 2023. Int J Biol Macromol. 237: 124073. PMID: 36934819
  10. The Substrate Specificity of Phospholipase A2: The Reaction of the Enzyme with 3-Octanoyloxy-4-Nitrobenzoic Acid  |  Michael A. Markowitz, John T. Seykora, F. J. Kézdy. 1985. 94: 1033-1037.
  11. Crystal structures of two (3-hydroxy-4-nitrobenzoato) complexes of magnesium(II): Ionic entities stabilized by stacking interactions and extensive hydrogen bonding  |  Georges Morgant a, Jean d'Angelo a, Didier Desmaële a, Emma Dichi b, Mehrez Sghaier b, Bernard Fraisse c, Pascal Retailleau d, Véronique Brumas e, Marina M.L. Fiallo e, Alain Tomas f. 2008. Polyhedron. 27: 2097-2104.
  12. A CONVENIENT REDUCTION OF HIGHLY FUNCTIONALIZED AROMATIC CARBOXYLIC ACIDS TO ALCOHOLS WITH BORANE-THF AND BORON TRIFLUORIDE-ETHERATE  |  M. H. Chen, E. Iakovleva, S. Kesten, J. Magano, D. Rodriguez, K. E. Sexton, show all. 2009. Organic Preparations and Procedures International. 34: 665-670.
  13. Tetraaqua-bis(3-hydroxy-4-nitrobenzoato) Co(II) and Ni(II) complexes and diaqua-bis(2-hydroxy-4-methoxybenzoato) Zn(II) complex: crystal structure and thorough metal-coordination investigation  |  , Georges Morgant, Didier Desmaële, Mehrez Sghaier, Emma Dichi, Bernard Fraisse. 2011. Journal of Coordination Chemistry. 64: 3110-3122.
  14. A new synthesis of tafamidis via zinc-MsOH mediated reductive cyclisation strategy  |  Kishore Karumanchi, Senthil Kumar Natarajan, Sunil Gadde, Krishna Vanchanagiri & Krishnamurthy V R Moturu. 2021. Journal of Chemical Sciences. 133: 48.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Hydroxy-4-nitrobenzoic acid, 25 g

sc-256513
25 g
$90.00