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3-Hydroxy-2-iodo-4-methoxybenzaldehyde (CAS 138490-94-5)

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Alternate Names:
2-Iodoisovanillin; 4-Formyl-2-hydroxy-3-iodoanisole
CAS Number:
138490-94-5
Molecular Weight:
278.04
Molecular Formula:
C8H7IO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Hydroxy-2-iodo-4-methoxybenzaldehyde is a yellowish-brown powder widely utilized in scientific research. This compound has garnered considerable attention due to its distinctive properties and finds extensive application in the field. Additionally, it serves as a valuable precursor for synthesizing various biologically active compounds. The mechanism of action of 3-Hydroxy-2-iodo-4-methoxybenzaldehyde involves the inhibition of protein tyrosine phosphatases (PTPs). These enzymes are responsible for removing phosphate groups from tyrosine residues in proteins. By inhibiting PTPs, 3-Hydroxy-2-iodo-4-methoxybenzaldehyde disrupts this essential function, leading to the accumulation of phosphorylated proteins. This accumulation can trigger cellular responses that ultimately result in cell death.


3-Hydroxy-2-iodo-4-methoxybenzaldehyde (CAS 138490-94-5) References

  1. Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities.  |  Markovich, KM., et al. 1992. J Med Chem. 35: 466-79. PMID: 1346651
  2. Cyclopropylmethyl Protection of Phenols: Total Synthesis of the Resveratrol Dimers Anigopreissin A and Resveratrol-Piceatannol Hybrid.  |  Kumar, A., et al. 2018. ChemistryOpen. 7: 953-956. PMID: 30524921
  3. Recyclable Pd/CuFe2O4 nanowires: a highly active catalyst for C-C couplings and synthesis of benzofuran derivatives.  |  Lakshminarayana, B., et al. 2018. RSC Adv. 8: 21030-21039. PMID: 35542338

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Hydroxy-2-iodo-4-methoxybenzaldehyde, 5 g

sc-226085
5 g
$133.00