Date published: 2026-5-3

1-800-457-3801

SCBT Portrait Logo
Seach Input

3-Fluoro-2-nitropyridine (CAS 54231-35-5)

0.0(0)
Write a reviewAsk a question

Alternate Names:
2-Nitro-3-fluoropyridine
Application:
3-Fluoro-2-nitropyridine is a specialty product for proteomics research applications
CAS Number:
54231-35-5
Molecular Weight:
142.09
Molecular Formula:
C5H3FN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

3-Fluoro-2-nitropyridine is a specialized chemical compound widely used in the field of organic synthesis and materials science for its role as a versatile intermediate in the construction of complex molecular architectures. This compound features a pyridine ring substituted with both fluoro and nitro groups, which significantly influence its electronic and chemical properties. The presence of the nitro group makes 3-Fluoro-2-nitropyridine an effective electrophile, enabling it to participate in various nucleophilic substitution reactions that are fundamental in synthesizing pharmaceuticals, agrochemicals, and dyes. In research, 3-Fluoro-2-nitropyridine is particularly valued for its utility in the synthesis of heterocyclic compounds, where its reactivity allows for the introduction of nitrogen-containing rings into more complex structures. This capability is crucial for developing new compounds with potential biological activity. Additionally, the fluoro group enhances the compound′s ability to act as a building block in the synthesis of liquid crystals and organic light-emitting diodes (OLEDs), contributing to advances in electronic and optoelectronic technologies. Researchers also explore 3-Fluoro-2-nitropyridine′s role in creating novel organofluorine compounds, which are important due to their stability and unique chemical properties in various industrial applications. Its application extends to studies on reaction kinetics and mechanisms, providing deeper insights into the behavior of substituted pyridines under different chemical conditions, thus advancing the field of synthetic organic chemistry.


3-Fluoro-2-nitropyridine (CAS 54231-35-5) References

  1. From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.  |  Gerusz, V., et al. 2012. J Med Chem. 55: 9914-28. PMID: 23092194
  2. Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.  |  Rzasa, RM., et al. 2012. Bioorg Med Chem Lett. 22: 7371-5. PMID: 23149228
  3. Solid-phase synthesis of 5-noranagrelide derivatives.  |  Messina, I., et al. 2014. ACS Comb Sci. 16: 33-8. PMID: 24304422
  4. Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines.  |  Beesu, M., et al. 2014. J Med Chem. 57: 7325-41. PMID: 25102141
  5. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.  |  Hinklin, RJ., et al. 2020. Bioorg Med Chem. 28: 115232. PMID: 31818630
  6. Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.  |  Visser, M., et al. 2024. J Med Chem. 67: 1447-1459. PMID: 38198520

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Fluoro-2-nitropyridine, 1 g

sc-260921
1 g
$100.00

3-Fluoro-2-nitropyridine, 5 g

sc-260921A
5 g
$300.00