Date published: 2025-10-14

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3-Fluoro-1,2-propanediol (CAS 453-16-7)

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Alternate Names:
α-Fluorohydrin
CAS Number:
453-16-7
Molecular Weight:
94.08
Molecular Formula:
C3H7FO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Fluoro-1,2-propanediol is a compound that functions as a building block in organic synthesis. It is used to introduce a fluorine atom into various organic molecules, serving as a precursor in the production of agrochemicals, and materials. The mechanism of action involves the substitution of a hydroxyl group with a fluorine atom, resulting in the formation of new carbon-fluorine bonds. This substitution reaction is in the synthesis of fluorinated compounds, which are of interest in medicinal chemistry and materials science. 3-Fluoro-1,2-propanediol′s role in introducing fluorine atoms into organic molecules is significant for the development of new compounds with potentially enhanced properties or biological activities. Its ability to modify the structure of organic molecules through fluorination reactions makes it a function in the synthesis of diverse chemical compounds for development purposes.


3-Fluoro-1,2-propanediol (CAS 453-16-7) References

  1. Mechanism of action of adenosylcobalamin: 3-fluoro-1,2-propranediol as substrate for propanediol dehydrase--mechanistic implications.  |  Eagar, RG., et al. 1975. Biochemistry. 14: 5523-8. PMID: 1201278
  2. Key enzymes enabling the growth of Arthrobacter sp. strain JBH1 with nitroglycerin as the sole source of carbon and nitrogen.  |  Husserl, J., et al. 2012. Appl Environ Microbiol. 78: 3649-55. PMID: 22427495
  3. The preferred all-gauche conformations in 3-fluoro-1,2-propanediol.  |  Andrade, LA., et al. 2013. Org Biomol Chem. 11: 6766-71. PMID: 23995049
  4. Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.  |  Lu, J., et al. 2018. Biochemistry. 57: 3465-3472. PMID: 29733591
  5. Conformational signature of Ishikawa´s reagent using NMR information from diastereotopic fluorines.  |  Andrade, LAF., et al. 2019. Beilstein J Org Chem. 15: 506-512. PMID: 30873234

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Fluoro-1,2-propanediol, 250 mg

sc-214130
250 mg
$197.00