Date published: 2025-10-16

1-800-457-3801

SCBT Portrait Logo
Seach Input

3-Dimethylamino-1-propyne (CAS 7223-38-3)

0.0(0)
Write a reviewAsk a question

Alternate Names:
1-Dimethylamino-2-propyne; N,N-Dimethyl-2-propynylamine; N,N-Dimethylpropargylamine
CAS Number:
7223-38-3
Molecular Weight:
83.13
Molecular Formula:
C5H9N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

3-Dimethylamino-1-propyne, known as 3-DMAP, is a versatile organic compound employed in various scientific and industrial applications. As a colorless liquid with a sweet odor, it easily dissolves in most organic solvents. Its widespread utilization spans multiple domains, including the synthesis of agrochemicals and other compounds, making it an indispensable reagent. In scientific research, 3-Dimethylamino-1-propyne finds application as a catalyst in polymer synthesis, notably in the creation of polyurethanes and polyesters. Furthermore, it plays a role in the production of dyes, pigments, and fluorescent compounds. The compound′s unique nucleophilic nature allows it to react with compounds containing an electrophilic center, thus enabling the synthesis of a diverse range of compounds. Additionally, 3-Dimethylamino-1-propyne acts as an efficient acid catalyst, facilitating the formation of various compounds. Given its multiple roles and exceptional properties, 3-Dimethylamino-1-propyne remains a valuable and sought-after element in the realm of scientific exploration and industrial processes.


3-Dimethylamino-1-propyne (CAS 7223-38-3) References

  1. Proceedings: Monoamine oxidase active site; the binding to and titration of monoamine oxidase with (14C)-selective inhibitors.  |  Youdim, MB. 1976. Br J Pharmacol. 56: 375P. PMID: 1260203
  2. Core shell hybrids based on noble metal nanoparticles and conjugated polymers: synthesis and characterization.  |  Fratoddi, I., et al. 2011. Nanoscale Res Lett. 6: 98. PMID: 21711612
  3. Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.  |  Bai, S., et al. 2014. J Med Chem. 57: 4239-51. PMID: 24821398
  4. One-pot synthesis of functionalized germanium nanocrystals from a single source precursor.  |  Purkait, TK., et al. 2015. Nanoscale. 7: 2241-4. PMID: 25565561
  5. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.  |  Wang, HY., et al. 2016. J Med Chem. 59: 4913-25. PMID: 27050842
  6. Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.  |  Do, HT., et al. 2017. J Med Chem. 60: 9360-9375. PMID: 29091437
  7. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.  |  Beyett, TS., et al. 2018. Bioorg Med Chem. 26: 5443-5461. PMID: 30270002
  8. Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.  |  Do, HT., et al. 2019. J Med Chem. 62: 2690-2707. PMID: 30802056
  9. Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors.  |  Buron, F., et al. 2021. Molecules. 26: PMID: 34500781
  10. Chemistry of gas-phase sequencing: alternative bases.  |  Braunitzer, G. and Huber, F. 1987. Biol Chem Hoppe Seyler. 368: 195-8. PMID: 3593538
  11. Anti-Mold Protection of Textile Surfaces with Cold Plasma Produced Biocidal Nanocoatings.  |  Tyczkowska-Sieroń, E., et al. 2022. Materials (Basel). 15: PMID: 36234173
  12. Understanding the Effect of Triazole on Crosslinked PPO-SEBS-Based Anion Exchange Membranes for Water Electrolysis.  |  Choi, J., et al. 2023. Polymers (Basel). 15: PMID: 37050350
  13. [3-Dimethylamino-1-propyne as a buffer substance].  |  Braunitzer, G. and Schrank, B. 1970. Hoppe Seylers Z Physiol Chem. 351: 417. PMID: 5420716

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Dimethylamino-1-propyne, 5 g

sc-238535
5 g
$22.00