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3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one (CAS 55314-16-4)

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Alternate Names:
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one; 3-[3-(Dimethylamino)acryloyl]pyridine
Application:
CAS Number:
55314-16-4
Molecular Weight:
176.22
Molecular Formula:
C10H12N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is an Imatinib intermediate.


3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one (CAS 55314-16-4) References

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  2. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.  |  Buchdunger, E., et al. 2000. J Pharmacol Exp Ther. 295: 139-45. PMID: 10991971
  3. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study.  |  van Oosterom, AT., et al. 2001. Lancet. 358: 1421-3. PMID: 11705489
  4. Design, synthesis and biological activities of Nilotinib derivates as antitumor agents.  |  Pan, X., et al. 2013. Bioorg Med Chem. 21: 2527-34. PMID: 23538233
  5. Imatinib analogs as potential agents for PET imaging of Bcr-Abl and c-KIT expression at a kinase level.  |  Peng, Z., et al. 2014. Bioorg Med Chem. 22: 623-32. PMID: 24280068
  6. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors.  |  Hu, H., et al. 2020. Bioorg Chem. 102: 104064. PMID: 32653610
  7. Synthesis and antiinflammatory activity of trisubstituted pyrimidines and triazines.  |  Bennett, GB., et al. 1978. J Med Chem. 21: 623-8. PMID: 671461

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 1 g

sc-216433
1 g
$205.00