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3-Deazauridine (CAS 23205-42-7)

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Application:
3-Deazauridine is an antimetabolite antiviral (Flaviviridae) for proteomics research
CAS Number:
23205-42-7
Molecular Weight:
243.21
Molecular Formula:
C10H13NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Deazauridine is a synthetic analog of the nucleoside uridine and is of interest in biochemical research, particularly in the study of nucleic acid synthesis and function. Its structure, which lacks the 3-nitrogen in the pyrimidine ring, makes it a unique tool for investigating the mechanisms of RNA and DNA synthesis. Researchers utilize 3-deazauridine to investigate the inhibition of nucleotide reductase and cytidine deaminase, enzymes that are for the synthesis and modification of the nucleic acids. By incorporating into RNA in place of uridine, 3-deazauridine allows for the exploration of RNA function and stability, as well as protein synthesis, since RNA is directly involved in the translation process. Furthermore, this compound is of particular interest in the field of virology, where it is used to study viral replication and the potential to halt the proliferation of viruses by interfering with their genetic material. Its role in the manipulation of gene expression is also a key area of research, providing insights into the regulation of genetic pathways.


3-Deazauridine (CAS 23205-42-7) References

  1. 3-Deazauridine triggers dose-dependent apoptosis in myeloid leukemia cells and enhances retinoic acid-induced granulocytic differentiation of HL-60 cells.  |  Savickiene, J. and Gineitis, A. 2003. Int J Biochem Cell Biol. 35: 1482-94. PMID: 12818243
  2. 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase.  |  Raynal, NJ., et al. 2011. Leuk Res. 35: 110-8. PMID: 20510451
  3. The effect of 3-deazauridine and dipyridamole on uridine utilization by mice.  |  Moyer, JD., et al. 1986. Eur J Cancer Clin Oncol. 22: 323-7. PMID: 2423341
  4. Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2'-deoxycytidine and 3-deazauridine.  |  Momparler, RL. and Momparler, LF. 1989. Cancer Chemother Pharmacol. 25: 51-4. PMID: 2480188
  5. Inhibition of RNA virus replication in vitro by 3-deazacytidine and 3-deazauridine.  |  Khare, GP., et al. 1972. Proc Soc Exp Biol Med. 140: 880-4. PMID: 4339065
  6. Drug sequence-dependent toxicity and small bowel mucosal injury in mice treated with low doses of 3-deazauridine and 1-beta-D-arabinofuranosylcytosine.  |  Paterson, AR., et al. 1979. Cancer Res. 39: 2216-9. PMID: 445420
  7. 3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.  |  Shannon, WM., et al. 1972. Antimicrob Agents Chemother. 2: 159-63. PMID: 4799550
  8. Regulation of pyrimidine biosynthesis in cultured L1210 cells by 3-deazauridine.  |  Karle, JM. and Cysyk, RL. 1984. Biochem Pharmacol. 33: 3739-42. PMID: 6095859
  9. Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts.  |  Grant, S. and Cadman, E. 1980. Cancer Res. 40: 4000-6. PMID: 6162541
  10. Transport of uridine and 3-deazauridine in cultured human lymphoblastoid cells.  |  Dahlig-Harley, E., et al. 1984. Cancer Res. 44: 161-5. PMID: 6580947
  11. Cytotoxic and biochemical effects of thymidine and 3-deazauridine on human tumor cells.  |  Lockshin, A., et al. 1984. Cancer Res. 44: 2534-9. PMID: 6722792
  12. The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate.  |  van Berg, AA., et al. 1995. Biochem Pharmacol. 50: 1095-8. PMID: 7575666
  13. Effects of 2-deoxy-D-glucose and 3 deazauridine individually and in combination on the replication of Japanese B encephalitis virus.  |  Woodman, DR. and Williams, JC. 1977. Antimicrob Agents Chemother. 11: 475-81. PMID: 856001

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Deazauridine, 100 mg

sc-394445
100 mg
$357.00