3-Deazaadenosine (CAS 6736-58-9)
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3-Deazaadenosine is a compound of interest within molecular biology and biochemistry for its unique ability to act as an adenosine analog, which alters various biochemical pathways. Its mechanism of action is centered around the inhibition of S-adenosylhomocysteine hydrolase, leading to a reduction in methylation reactions within the cell, a critical area of study for understanding epigenetic regulation. This has prompted extensive research into its influence on gene expression and the potential implications for cellular differentiation and development. Additionally, 3-deazaadenosine is studied regarding how it affects the purine salvage pathways that are for the survival of some parasites, providing useful for dissecting the role of these pathways in parasitic life cycles. In biochemical research, it also serves as a chemical probe to investigate the influence of methylation on protein function and nucleic acid integrity, broadening the understanding of cellular homeostasis mechanisms.
3-Deazaadenosine (CAS 6736-58-9) References
- 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. | Jeong, SY., et al. 1999. J Biol Chem. 274: 18981-8. PMID: 10383397
- 3-deazaadenosine prevents adhesion molecule expression and atherosclerotic lesion formation in the aortas of C57BL/6J mice. | Walker, G., et al. 1999. Arterioscler Thromb Vasc Biol. 19: 2673-9. PMID: 10559010
- Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents. | Liu, MC., et al. 2001. Nucleosides Nucleotides Nucleic Acids. 20: 1975-2000. PMID: 11794802
- 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice. | Langheinrich, AC., et al. 2009. Atherosclerosis. 202: 103-10. PMID: 18495128
- Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis. | Mairhofer, E., et al. 2016. Beilstein J Org Chem. 12: 2556-2562. PMID: 28144324
- Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases. | Zhang, B., et al. 2018. Eur J Med Chem. 148: 384-396. PMID: 29477072
- 3-Deazaadenosine, an S-adenosylhomocysteine hydrolase inhibitor, attenuates lipopolysaccharide-induced inflammatory responses via inhibition of AP-1 and NF-κB signaling. | Yang, WS., et al. 2020. Biochem Pharmacol. 182: 114264. PMID: 33035507
- Convenient Synthesis of 3-Deazapurine Nucleosides (3-Deazainosine, 3-Deazaadenosine and 3-Deazaguanosine) Using Inosine as a Starting Material. | Hinotani, N., et al. 2021. Curr Protoc. 1: e297. PMID: 34837670
- 3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice. | Guerrero, A., et al. 2022. Nat Aging. 2: 851-866. PMID: 36438588
- lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m6A reader YTHDC2. | Wang, J., et al. 2022. Mol Cancer. 21: 229. PMID: 36581942
- 3-Deazaadenosine keeps senescence at bay. | Guerrero, A. and Gil, J. 2023. Aging (Albany NY). 15: 2369-2370. PMID: 36988502
- 3-Deazaadenosine-induced disorganization of macrophage microfilaments. | Stopford, CR., et al. 1985. Proc Natl Acad Sci U S A. 82: 4060-4. PMID: 3858863
- 3-Deazaadenosine and MDL29350 differentially affect the methylation of serine-and ethanolamine-derived phosphatidylethanolamine in Hep G2 cells. | Lu, X., et al. 1993. Metabolism. 42: 1506-8. PMID: 8246762
- 3-Deazaadenosine analogues inhibit the production of tumour necrosis factor-alpha in RAW264.7 cells stimulated with lipopolysaccharide. | Jeong, SY., et al. 1996. Immunology. 89: 558-62. PMID: 9014821
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Deazaadenosine, 5 mg | sc-216428 | 5 mg | $357.00 | |||
3-Deazaadenosine, 10 mg | sc-216428A | 10 mg | $525.00 |