Molecular structure of 3-Cysteinylacetaminophen trifluoroacetic acid salt, CAS Number: 1331891-93-0
3-Cysteinylacetaminophen trifluoroacetic acid salt (CAS 1331891-93-0)
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Alternate Names:
S[5-(Acetylamino)-2-hydroxyphenyl]-L-cysteine Trifluoroacetic Acid Salt; APAP-CYS trifluoroacetic acid salt
Application:
3-Cysteinylacetaminophen trifluoroacetic acid salt is an acetaminophen metabolite
CAS Number:
1331891-93-0
Purity:
≥95%
Molecular Weight:
384.33
Molecular Formula:
C11H14N2O4S•C2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Cysteinylacetaminophen Trifluoroacetic Acid Salt is an acetaminophen metabolite implicated in nephrotoxicity. This compound has been used in research to study the metabolism and toxicology of acetaminophen. Specifically, it is used to investigate the role of glutathione, a natural antioxidant molecule, in protecting against acetaminophen-induced liver damage. In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin.
3-Cysteinylacetaminophen trifluoroacetic acid salt (CAS 1331891-93-0) References
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- Magnetic beads as an extraction medium for simultaneous quantification of acetaminophen and structurally related compounds in human serum. | Bylda, C., et al. 2015. Drug Test Anal. 7: 457-66. PMID: 25231125
- Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: clinical and animal model applications. | Cook, SF., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 985: 131-41. PMID: 25681644
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- A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition. | Wang, YX., et al. 2019. Chin J Nat Med. 17: 517-524. PMID: 31514983
- The Impact of Proximal Roux-en-Y Gastric Bypass Surgery on Acetaminophen Absorption and Metabolism. | Chen, KF., et al. 2020. Pharmacotherapy. 40: 191-203. PMID: 31960977
- Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates. | Koenderink, JB., et al. 2020. Arch Toxicol. 94: 3027-3032. PMID: 32472168
- The use of alkoxycarbonyl derivatives for the mass spectral analysis of drug-thioether metabolites. Studies with the cysteine, mercapturic acid and glutathione conjugates of acetaminophen. | Hoffmann, KJ. and Baillie, TA. 1988. Biomed Environ Mass Spectrom. 15: 637-47. PMID: 3416089
- Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme. | Yang, W., et al. 2022. Molecules. 27: PMID: 36557984
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Cysteinylacetaminophen trifluoroacetic acid salt, 2.5 mg | sc-209586 | 2.5 mg | $614.00 |