Molecular structure of 3-Chloro-5-hydroxybenzoic acid, CAS Number: 53984-36-4
3-Chloro-5-hydroxybenzoic acid (CAS 53984-36-4)
See product citations (2)
Alternate Names:
3-Chloro-5-hydroxy-benzoic acid; 5-Chloro-m-salicylic Acid; 3-Hydroxy-5-chlorobenzoic Acid
Application:
3-Chloro-5-hydroxybenzoic acid is an activator of FKSG80
CAS Number:
53984-36-4
Purity:
97%
Molecular Weight:
172.57
Molecular Formula:
C7H5ClO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Chloro-5-hydroxybenzoic acid (C7H5ClO3) is a derivative of benzoic acid with a chlorine atom and a hydroxyl group attached to the benzene ring. It acts as a selective agonist of the lactate receptor, GPR81 (FKSG80), which plays a role in regulating triglyceride lipolysis in adipose tissue. With its acidic and phenolic properties, this compound is versatile in participating in esterification, condensation, and other organic transformations.
3-Chloro-5-hydroxybenzoic acid (CAS 53984-36-4) References
- Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. | Engelstoft, MS., et al. 2013. Mol Metab. 2: 376-92. PMID: 24327954
- Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects. | Dvorak, CA., et al. 2012. ACS Med Chem Lett. 3: 637-9. PMID: 24900524
- Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer. | Ristic, B., et al. 2017. Biochim Biophys Acta Rev Cancer. 1868: 246-257. PMID: 28512002
- GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. | Ranganathan, P., et al. 2018. J Immunol. 200: 1781-1789. PMID: 29386257
- Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP. | Vardjan, N., et al. 2018. Front Mol Neurosci. 11: 148. PMID: 29867342
- The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits. | de Castro Abrantes, H., et al. 2019. J Neurosci. 39: 4422-4433. PMID: 30926749
- The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment. | Brown, TP., et al. 2020. Oncogene. 39: 3292-3304. PMID: 32071396
- Novel pH-responsive nanovectors for controlled release of ionisable drugs. | Mastrotto, F., et al. 2013. J Mater Chem B. 1: 5335-5346. PMID: 32263336
- L-lactate induces neurogenesis in the mouse ventricular-subventricular zone via the lactate receptor HCA1. | Lambertus, M., et al. 2021. Acta Physiol (Oxf). 231: e13587. PMID: 33244894
- Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion. | Buscemi, L., et al. 2021. Front Physiol. 12: 689239. PMID: 34093243
- Lactate activates hypothalamic POMC neurons by intercellular signaling. | Órdenes, P., et al. 2021. Sci Rep. 11: 21644. PMID: 34737351
- HCAR1-Mediated L-Lactate Signaling Suppresses Microglial Phagocytosis. | Nicola, R., et al. 2022. Neuromolecular Med. 24: 399-404. PMID: 35411485
- Activation of GPR81 Aggravates Remote Organ Injury During Hepatic Ischemia-Reperfusion Injury. | Zan, X., et al. 2022. Transplant Proc. 54: 1992-1997. PMID: 35902290
- Activation of brain lactate receptor GPR81 aggravates exercise-induced central fatigue. | Li, J., et al. 2022. Am J Physiol Regul Integr Comp Physiol. 323: R822-R831. PMID: 36189986
Activator of:
FKSG80.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Chloro-5-hydroxybenzoic acid, 200 mg | sc-276161 | 200 mg | $197.00 |