Date published: 2026-5-22

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3-Chloro-4-fluoroaniline (CAS 367-21-5)

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CAS Number:
367-21-5
Molecular Weight:
145.56
Molecular Formula:
C6H5ClFN
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Chloro-4-fluoroaniline (3-CF) is a versatile organic compound that finds extensive application across diverse scientific disciplines. As a heterocyclic aromatic amine, it possesses both carbon and nitrogen atoms within its structure. 3-CF also contributes to the creation of materials such as plastics, rubbers, and adhesives. Its potential impact on biochemistry and physiology has garnered scientific interest. 3-Chloro-4-fluoroaniline has been extensively utilized in scientific research, serving as a model compound for investigating the influence of fluoroalkyl groups on organic molecule properties. Additionally, it has been instrumental in examining the impact of halogen substitution on the reactivity of aromatic amines. The compound has also proven invaluable in elucidating the mechanisms underlying electrophilic aromatic substitution reactions. The mechanism of action for 3-Chloro-4-fluoroaniline hinges on its capacity to partake in electrophilic aromatic substitution reactions with nucleophilic molecules. This reaction entails the formation of a covalent bond between the electrophile (3-Chloro-4-fluoroaniline) and the nucleophile. Typically, a Lewis acid, such as sulfuric acid or hydrochloric acid, acts as a catalyst, facilitating the reaction.


3-Chloro-4-fluoroaniline (CAS 367-21-5) References

  1. Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR.  |  Duckett, CJ., et al. 2006. Xenobiotica. 36: 59-77. PMID: 16507513
  2. Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.  |  Smaill, JB., et al. 2016. J Med Chem. 59: 8103-24. PMID: 27491023
  3. An improved analytical method, based on HPLC with electrochemical detection, for monitoring exposure to 3-chloro-4-fluoroaniline.  |  Eadsforth, CV., et al. 1988. J Anal Toxicol. 12: 330-3. PMID: 3244272
  4. Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry.  |  Wang, C., et al. 2020. PLoS One. 15: e0236523. PMID: 32702075
  5. Deducing the Conformational Properties of a Tyrosine Kinase Inhibitor in Solution by Optical Spectroscopy and Computational Chemistry.  |  Kabir, ML., et al. 2020. Front Chem. 8: 596. PMID: 32850633
  6. [A high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of four genotoxic impurities in gefitinib].  |  Sun, C., et al. 2019. Se Pu. 37: 1297-1304. PMID: 34213131
  7. Biological monitoring of exposure to 3-chloro-4-fluoroaniline by determination of a urinary metabolite and a hemoglobin adduct.  |  Boogaard, PJ., et al. 1994. Environ Health Perspect. 102 Suppl 6: 23-5. PMID: 7889853

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Chloro-4-fluoroaniline, 25 g

sc-254455
25 g
$43.00