Molecular structure of 3-Bromo-7-nitroindazole sodium salt
3-Bromo-7-nitroindazole sodium salt (CAS 74209-34-0 free base)
Application:
3-Bromo-7-nitroindazole sodium salt is a potent NOS1 inhibitor
CAS Number:
74209-34-0 free base
Molecular Weight:
264.0
Molecular Formula:
C7H3BrN3O2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Bromo-7-nitroindazole sodium salt is the salt form of 3-bromo-7-nitroindazole (sc-200347). 3-Bromo-7-nitroindazole is a strong inhibitor of rat NOS1 (cerebellar nitric oxide synthase/nNOS). This compound is a stronger inhibitor than 7-nitroindazole (sc-3569).
3-Bromo-7-nitroindazole sodium salt (CAS 74209-34-0 free base) References
7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase: P.A. Bland-Ward & P.K. Moore; Life Sci. 57, PL131 (1995) Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro: J. Wu, et al.; Neuroscience 78, 393 (1997) Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy: D.B. Vaupel, et al.; Eur. J. Pharmacol. 324, 11 (1997) 3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles: S.C. Gammie, et al.; Brain Res. 870, 80 (2000) Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism: C.S. Raman, et al.; Biochemistry 40, 13448 (2001) Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat: M. Cavas & J.F. Navarro; Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 56 (2006)Inhibitor of:
NOS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Bromo-7-nitroindazole sodium salt, 25 mg | sc-220856 | 25 mg | $200.00 | |||
3-Bromo-7-nitroindazole sodium salt, 100 mg | sc-220856A | 100 mg | $100.00 | |||
3-Bromo-7-nitroindazole sodium salt, 500 mg | sc-220856B | 500 mg | $400.00 |