Date published: 2025-9-14

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3-amino-N-(tert-butyl)benzenesulfonamide (CAS 608523-94-0)

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Alternate Names:
N-t-Butyl 3-aminobenzenesulfonamide; 3-Amino-N-t-butylbenzenesulfonamide
Application:
3-amino-N-(tert-butyl)benzenesulfonamide is a useful sulfonamide for proteomics research
CAS Number:
608523-94-0
Molecular Weight:
228.31
Molecular Formula:
C10H16N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Amino-N-(tert-butyl)benzenesulfonamide (3-ATBBS), a sulfonamide derivative, finds extensive use in diverse scientific applications. This molecule exhibits versatility, making it suitable for various experiments exploring biochemical effects. The scientific applications of 3-amino-N-(tert-butyl)benzenesulfonamide span a wide range. Notably, it has been utilized in studies focusing on the inhibition of enzymes, such as dihydrofolate reductase, which plays a vital role in folate metabolism. It has been in investigations targeting the inhibition of protein tyrosine phosphatases, key regulators of cell signaling pathways. 3-amino-N-(tert-butyl)benzenesulfonamide has been instrumental in studies investigating the inhibition of xanthine oxidase, an enzyme involved in purine metabolism. The precise mechanism of action for 3-amino-N-(tert-butyl)benzenesulfonamide remains incompletely understood. Current understanding suggests that it acts as an enzyme inhibitor by binding to the active site of the enzyme, consequently obstructing substrate binding.


3-amino-N-(tert-butyl)benzenesulfonamide (CAS 608523-94-0) References

  1. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.  |  Tamayo, NA., et al. 2022. J Med Chem. 65: 4972-4990. PMID: 35286090
  2. Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.  |  Qiu, Q., et al. 2023. J Med Chem. 66: 5753-5773. PMID: 37057760

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-amino-N-(tert-butyl)benzenesulfonamide, 1 g

sc-276023
1 g
$102.00