3-Amino-N-butylbenzamide (CAS 6837-99-6)
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4-HQN may act to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. Experiments have shown that this compound specifically and potently inhibits PARP-1. Other studies suggest that 4-HQN demonstrates the ability to decrease activation of transcription factor NFkappaB and AP-1 in lipopolysaccharide-induced endotoxic shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Amino-N-butylbenzamide, 500 mg | sc-312454 | 500 mg | $284.00 |