Date published: 2025-9-14

1-800-457-3801

SCBT Portrait Logo
Seach Input

3-Amino-4-bromo-6-chloropyridazine (CAS 446273-59-2)

0.0(0)
Write a reviewAsk a question

Alternate Names:
4-Bromo-6-chloropyridazin-3-amine
CAS Number:
446273-59-2
Molecular Weight:
208.44
Molecular Formula:
C4H3BrClN3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

3-Amino-4-bromo-6-chloropyridazine, a heterocyclic compound, has garnered significant attention in scientific research due to its versatile applications in organic synthesis and material science. With its unique structure comprising bromine, chlorine, and amino groups attached to a pyridazine ring, this compound serves as a valuable building block for the synthesis of various pharmaceutical intermediates and functional materials. In organic synthesis, 3-amino-4-bromo-6-chloropyridazine acts as a key reagent for the construction of diverse pyridazine derivatives, which exhibit a wide range of biological activities and pharmacological properties. Its bromo and chloro substituents facilitate selective functionalization reactions, enabling the introduction of different functional groups at specific positions of the pyridazine ring. Moreover, this compound has found applications in the development of novel organic light-emitting diodes (OLEDs), where it serves as an electron transport material due to its favorable electronic properties. The presence of electron-donating and electron-withdrawing substituents enhances its electron affinity and conductivity, making it suitable for use in optoelectronic devices. Furthermore, researchers have explored the potential of 3-amino-4-bromo-6-chloropyridazine in the synthesis of conjugated polymers and organic semiconductors for applications in organic photovoltaics and light-emitting devices. Its versatility as a synthetic building block and its role in the fabrication of functional materials highlight its importance in advancing scientific research across multiple disciplines, including organic chemistry, materials science, and electronics.


3-Amino-4-bromo-6-chloropyridazine (CAS 446273-59-2) References

  1. Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors.  |  Mao, B., et al. 2017. Eur J Med Chem. 129: 135-150. PMID: 28235701
  2. Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.  |  Colombano, G., et al. 2019. J Med Chem. 62: 2447-2465. PMID: 30779566
  3. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.  |  Wanior, M., et al. 2020. J Med Chem. 63: 14680-14699. PMID: 33216538
  4. Novel insecticidal 1,6-dihydro-6-iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors.  |  Liu, G., et al. 2022. Pest Manag Sci. 78: 2872-2882. PMID: 35396824
  5. Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.  |  Břehová, P., et al. 2023. J Med Chem. 66: 11133-11157. PMID: 37535845
  6. PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.  |  Berlin, M., et al. 2024. J Med Chem. 67: 1262-1313. PMID: 38180485
  7. Synthesis of Imidazo [1, 2‐b] pyridazine Scaffold Based Amide Derivatives as Potential Inhibitors for Bacterial Activity.  |  Yesubabu, Neelam, et al. 2024. ChemistrySelect. 9.19: e202400735.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Amino-4-bromo-6-chloropyridazine, 1 g

sc-322364
1 g
$160.00

3-Amino-4-bromo-6-chloropyridazine, 5 g

sc-322364A
5 g
$242.00