Molecular structure of 3-Amino-1,2,4-triazole, CAS Number: 61-82-5
3-Amino-1,2,4-triazole (CAS 61-82-5)
See product citations (5)
Alternate Names:
Aminotriazole; Amitrole
Application:
3-Amino-1,2,4-triazole is an irreversible catalase inhibitor
CAS Number:
61-82-5
Purity:
≥95%
Molecular Weight:
84.08
Molecular Formula:
C2H4N4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
3-Amino-1,2,4-triazole is a small molecule irreversible inhibitor of catalase, an enzyme responsible for converting cellular H2O2 into H2O and O2. Impeding the natural clearance of H2O2 from the cell by catalase has proven useful in studies investigating free radical-mediated damage of cardiac tissue in ischemia. 3-Amino-1,2,4-triazole also shows inhibition of imidazoleglycerol-phosphate dehydratase (HIS3) activity, which interrupts the biosynthesis of histidines. When 3-Amino-1,2,4-triazole is diazotized, the resulting 3-Diazo-1,2,4-triazole is shown to react specifically with tryptophan at acidic pH, presenting a method for determining the tryptophan content of proteins.
3-Amino-1,2,4-triazole (CAS 61-82-5) References
- A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions. | Joung, JK., et al. 2000. Proc Natl Acad Sci U S A. 97: 7382-7. PMID: 10852947
- 3-amino-1,2,4-triazole inhibits macrophage NO synthase. | Buchmüller-Rouiller, Y., et al. 1992. Biochem Biophys Res Commun. 183: 150-5. PMID: 1371917
- Dose- and time-dependent effect of an acute 3-amino-1,2,4-triazole injection on rat brain catalase activity. | Aragon, CM., et al. 1991. Biochem Pharmacol. 42: 699-702. PMID: 1859472
- Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles. | Noël, R., et al. 2009. J Org Chem. 74: 7595-7. PMID: 19731897
- Impact of 3-Amino-1,2,4-Triazole (3-AT)-Derived Increase in Hydrogen Peroxide Levels on Inflammation and Metabolism in Human Differentiated Adipocytes. | Ruiz-Ojeda, FJ., et al. 2016. PLoS One. 11: e0152550. PMID: 27023799
- 3-Amino-1,2,4-triazole Limits the Oxidative Damage in UVA-Irradiated Dysplastic Keratinocytes. | Nechifor, MT. and Dinu, D. 2017. Biomed Res Int. 2017: 4872164. PMID: 29387721
- Strategies for synthesis of 1,2,4-triazole-containing scaffolds using 3-amino-1,2,4-triazole. | Nasri, S., et al. 2022. Mol Divers. 26: 717-739. PMID: 33608844
- Structure and IR spectroscopic properties of complexes of 1,2,4-triazole and 3-amino-1,2,4-triazole with dinitrogen isolated in solid argon. | Mucha, K., et al. 2023. Spectrochim Acta A Mol Biomol Spectrosc. 285: 121901. PMID: 36182831
- The reaction of 3-diazonium-1,2,4-triazole with tryptophan at acid pH: a scintillation method for tryptophan determination in proteins. | DeTraglia, MC., et al. 1979. Anal Biochem. 99: 464-73. PMID: 574724
- Specific regulatory interconnection between the leucine and histidine pathways of Neurospora crassa. | Kidd, GL. and Gross, SR. 1984. J Bacteriol. 158: 121-7. PMID: 6325383
- Mechanisms of increasing expression of a yeast gene in Escherichia coli. | Brennan, MB. and Struhl, K. 1980. J Mol Biol. 136: 333-8. PMID: 6990004
- Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats. | Auyeung, Y., et al. 1995. Circulation. 92: 3318-22. PMID: 7586320
- Effect of 3-aminotriazole on hyperthermia-mediated cardioprotection in rabbits. | Kingma, JG., et al. 1996. Am J Physiol. 270: H1165-71. PMID: 8967353
Inhibitor of:
Catalase, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Amino-1,2,4-triazole, 10 g | sc-202016 | 10 g | $51.00 | |||
3-Amino-1,2,4-triazole, 100 g | sc-202016A | 100 g | $153.00 |