Molecular structure of 3-Acetylpyridine adenine dinucleotide, CAS Number: 86-08-8
3-Acetylpyridine adenine dinucleotide (CAS 86-08-8)
See product citations (3)
Alternate Names:
APAD, Oxidized
Application:
3-Acetylpyridine adenine dinucleotide is an analog of NAD
CAS Number:
86-08-8
Purity:
≥92%
Molecular Weight:
662.44
Molecular Formula:
C22H28N6O14P2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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3-Acetylpyridine adenine dinucleotide is an NAD analog with higher oxidation potential than NAD. It can substitute for NAD as a hydrogen-accepting cofactor in many dehydrogenase reactions for example, lactate dehydrogenase from Toxoplasma, Clonorchis, and Plasmodium, bacterial lipoamide dehydrogenase, as well as mammalian dehydrogenases. This compound can also act as a proton acceptor in various transhydrogenation reactions with NADH or NADPH.
3-Acetylpyridine adenine dinucleotide (CAS 86-08-8) References
- The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum. | Dando, C., et al. 2001. Mol Biochem Parasitol. 118: 23-32. PMID: 11704270
- Kinetics of the transhydrogenase reaction catalyzed by mitochondrial NADH:ubiquinone oxidoreductase (complex I). | Zakharova, NV. 2002. Biochemistry (Mosc). 67: 651-61. PMID: 12126472
- Structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use. | Kavanagh, KL., et al. 2004. Biochemistry. 43: 879-89. PMID: 14744130
- Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis. | Yang, G., et al. 2006. Parasitol Res. 99: 55-64. PMID: 16479375
- Artificial electron carriers for photoenzymatic synthesis under visible light. | Lee, SH., et al. 2012. Chemistry. 18: 5490-5. PMID: 22488767
- An enzymatic cycling method for 3-acetylpyridine adenine dinucleotide to increase the sensitivity of enzymatic methods which employ this NAD analog. | Ferrier, B. 1990. Anal Biochem. 186: 229-32. PMID: 2363493
- Thioredoxin Reductase-Type Ferredoxin: NADP+ Oxidoreductase of Rhodopseudomonas palustris: Potentiometric Characteristics and Reactions with Nonphysiological Oxidants. | Lesanavičius, M., et al. 2022. Antioxidants (Basel). 11: PMID: 35624864
- Analysis of the kinetic mechanism of enterococcal NADH peroxidase reveals catalytic roles for NADH complexes with both oxidized and two-electron-reduced enzyme forms. | Crane, EJ., et al. 1995. Biochemistry. 34: 14114-24. PMID: 7578008
- The mechanism of hydride transfer between NADH and 3-acetylpyridine adenine dinucleotide by the pyridine nucleotide transhydrogenase of Escherichia coli. | Glavas, NA. and Bragg, PD. 1995. Biochim Biophys Acta. 1231: 297-303. PMID: 7578217
- High cyclic transhydrogenase activity catalyzed by expressed and reconstituted nucleotide-binding domains of Rhodospirillum rubrum transhydrogenase. | Yamaguchi, M. and Hatefi, Y. 1997. Biochim Biophys Acta. 1318: 225-34. PMID: 9030266
- Protein engineering tests of a homology model of Plasmodium falciparum lactate dehydrogenase. | Hewitt, CO., et al. 1997. Protein Eng. 10: 39-44. PMID: 9051732
- Catalytic properties of lipoamide dehydrogenase from Mycobacterium smegmatis. | Marcinkeviciene, J. and Blanchard, JS. 1997. Arch Biochem Biophys. 340: 168-76. PMID: 9143318
- The reduction of acetylpyridine adenine dinucleotide by NADH: is it a significant reaction of proton-translocating transhydrogenase, or an artefact? | Stilwell, SN., et al. 1997. Biochim Biophys Acta. 1320: 83-94. PMID: 9186780
- Mutations at tyrosine-235 in the mobile loop region of domain I protein of transhydrogenase from Rhodospirillum rubrum strongly inhibit hydride transfer. | Bizouarn, T., et al. 1997. Biochim Biophys Acta. 1320: 265-74. PMID: 9230921
- Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum. | Gomez, MS., et al. 1997. Mol Biochem Parasitol. 90: 235-46. PMID: 9497046
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Acetylpyridine adenine dinucleotide, 25 mg | sc-209519 | 25 mg | $105.00 | |||
3-Acetylpyridine adenine dinucleotide, 100 mg | sc-209519A | 100 mg | $304.00 |