![3-Acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid trifluoroacetat - chemical structure ima](https://media.scbt.com/product/3-acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo4-2-0oct-2-ene-2-carboxylic-acid-trifluoroacetat-structure_22_84_b_228401.jpg)
![3-Acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid trifluoroacetat - chemical structure ima](https://media.scbt.com/product/3-acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo4-2-0oct-2-ene-2-carboxylic-acid-trifluoroacetat-structure_22_84_t_228401.jpg "Molecular structure of 3-Acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid trifluoroacetat")
3-Acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid trifluoroacetat
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Withaferin A, a steroidal lactone that can be found in Withania somnifera, may act to have potent growth inhibitory activities. Withaferin A binds to Vimentin, the intermediate filament (IF) protein, and causes Vimentin filaments to aggregate in vitro. Additional experiments have reported Withaferin A to be a proteasome inhibitor, with a specific primary target for 20S proteasome 5 subunit. Withaferin A demonstrates the potential to inhibit NF B activation by prevention of tumor necrosis factor-activated I B kinase via a thioalkylation-sensitive redox mechanism. In other studies, Withaferin A was also observed to alter cytoskeletal architecture by covalently binding Annexin II and stimulating its basal F-actin cross-linking activity. Another characteristic of Withaferin A that has been noted is its ability to induce regeneration of axons and dendrites and also reconstruct pre and postsynapses in neurons.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid trifluoroacetat, 500 mg | sc-312251 | 500 mg | $240.00 |