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3,6-Diphenyl-1,2,4,5-tetrazine (CAS 6830-78-0)

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CAS Number:
6830-78-0
Molecular Weight:
234.26
Molecular Formula:
C14H10N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,6-Diphenyl-1,2,4,5-tetrazine (DPT) is a significant organic compound that has garnered attention in recent decades due to its exceptional properties. With its cyclic tetrazine derivative featuring an aromatic ring structure, 3,6-Diphenyl-1,2,4,5-tetrazine finds utility across various scientific applications. It serves as a versatile molecule in organic synthesis, catalysis, and fluorescence probing. Moreover, it has proven instrumental in exploring biological systems, including the detection of reactive oxygen species and the study of protein-protein interactions. In scientific research, 3,6-Diphenyl-1,2,4,5-tetrazine exhibits a broad range of applications. It serves as a fluorescent probe for detecting reactive oxygen species, including superoxide and hydrogen peroxide. The mechanism of action of 3,6-Diphenyl-1,2,4,5-tetrazine is not fully elucidated. However, it is postulated that the molecule′s aromatic rings interact with reactive oxygen species, resulting in the formation of a fluorescent complex. This complex can be detected through fluorescence spectroscopy. Furthermore, the molecule is believed to interact with proteins, potentially inducing structural and functional changes in the proteins.


3,6-Diphenyl-1,2,4,5-tetrazine (CAS 6830-78-0) References

  1. Scandium ion-promoted reduction of heterocyclic N=N double bond. Hydride transfer vs electron transfer.  |  Fukuzumi, S., et al. 2002. J Am Chem Soc. 124: 12566-73. PMID: 12381201
  2. Redox Potential Tuning of s-Tetrazine by Substitution of Electron-Withdrawing/Donating Groups for Organic Electrode Materials.  |  Min, DJ., et al. 2021. Molecules. 26: PMID: 33567761
  3. Clip to Click: Controlling Inverse Electron-Demand Diels-Alder Reactions with Macrocyclic Tetrazines.  |  Novianti, I., et al. 2022. Org Lett. 24: 3223-3226. PMID: 35446571
  4. Reaction of 3,6-diphenyl-1,2,4,5-tetrazine with cis,cis-1,5-cyclooctadiene: An attempt at preparing some dihydropyridazine derivatives  |  S. Satish, A. Mitra, M.V. George ∗. 1979. Tetrahedron. 35: 277-285.
  5. Diels-alder reactions of 3, 6-diphenyl-1, 2, 4, 5-tetrazine and 3, 6-di(2-pyridyl)-1, 2, 4, 5-tetrazine with some 1-morpholinocycloalkenes  |  M. Adnan Atfah. 1989. Journal of Heterocyclic Chemistry. 26: 717-719.
  6. Design of nanoscale molecular wire based on 3, 6-Diphenyl-1, 2, 4, 5-Tetrazine and effect of external electric field on electron transfer in conjugated molecular wire  |  Z. Bayat a, S. Danesh nia a, S.J. Mahdizadeh b. 2011. Physica E: Low-dimensional Systems and Nanostructures. 43: 1569-1575.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,6-Diphenyl-1,2,4,5-tetrazine, 1 g

sc-232156
1 g
$69.00