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3,6-Diacetoxyphthalonitrile (CAS 83619-73-2)

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Application:
3,6-Diacetoxyphthalonitrile is an agent used for intracellular pH measurements using FCM
CAS Number:
83619-73-2
Purity:
≥98%
Molecular Weight:
244.20
Molecular Formula:
C12H8N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,6-Diacetoxyphthalonitrile is used for intracellular pH measurements using FCM, substrates, or Esterase substrates.


3,6-Diacetoxyphthalonitrile (CAS 83619-73-2) References

  1. Effects of procaine on the intracellular pH of Chinese hamster ovary cells heated at 42.0 or 45.0 degrees C.  |  Dynlacht, JR., et al. 1991. Radiat Res. 128: 14-8. PMID: 1924724
  2. Flow cytometric parameters of neutrophil function as early indicators of sepsis- or trauma-related pulmonary or cardiovascular organ failure.  |  Rothe, G., et al. 1990. J Lab Clin Med. 115: 52-61. PMID: 2105366
  3. Intracellular pH, esterase activity, and DNA measurements of human lung carcinomas by flow cytometry.  |  Liewald, F., et al. 1990. Cytometry. 11: 341-8. PMID: 2340771
  4. Intracellular pH of Chinese hamster ovary cells heated at 45.0 degrees C at pH 6.6.  |  Cook, JA. and Fox, MH. 1988. Radiat Res. 115: 96-105. PMID: 2839863
  5. [Use of 1,4 diacetoxy-2,3 dicyanobenzol in microspectrofluorometry for determining the intracellular pH of isolated living cells].  |  Alibaud, R., et al. 1988. C R Acad Sci III. 307: 89-92. PMID: 3144416
  6. Intracellular pH measurements using flow cytometry with 1,4-diacetoxy-2,3-dicyanobenzene.  |  Cook, JA. and Fox, MH. 1988. Cytometry. 9: 441-7. PMID: 3180945
  7. Development of thermotolerance and changes in intracellular pH in CHO cells heated at 45.0 degrees C at pH 6.6.  |  Cook, JA. and Fox, MH. 1988. Radiat Res. 115: 106-14. PMID: 3393626
  8. Cytostatic drug testing in human leukemias by means of multiparametric flow cytometry.  |  Neubauer, A., et al. 1987. Blut. 55: 433-45. PMID: 3676521
  9. New possibilities of cytostatic drug testing on patient tumor cells by flow cytometry.  |  Valet, G., et al. 1984. Blut. 49: 37-43. PMID: 6540134

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,6-Diacetoxyphthalonitrile, 5 mg

sc-214182
5 mg
$105.00

3,6-Diacetoxyphthalonitrile, 25 mg

sc-214182A
25 mg
$350.00

I want to make polymer beads that can indicate pH and am looking for a dye that can detect pH change in a the 4-9 range. I understand that 3,6-Diacetoxyphthalonitrile can be treated as a pH indicator, but in what range?

Asked by: ChemSynth123
Thank you for your question. 3,6-Diacetoxyphthalonitrile (CAS 83619-73-2): sc-214182 has been shown to change from blue to green with increasing pH in the range of 3.0 - 9.0.
Answered by: Chemical Support 7
Date published: 2017-03-03
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Rated 3 out of 5 by from We used the dye and got mixed resultsWe used the dye and got mixed results
Date published: 2015-05-06
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3,6-Diacetoxyphthalonitrile is rated 3.0 out of 5 by 1.
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