Date published: 2025-9-26

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3,5-Dimethylaniline (CAS 108-69-0)

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Alternate Names:
1-Amino-3,5-dimethylbenzene; 3,5-Xylidine; 5-Amino-m-xylene
CAS Number:
108-69-0
Molecular Weight:
121.18
Molecular Formula:
C8H11N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,5-Dimethylaniline is a liquid, ranging in color from clear to light brown, and emits a distinctive amine scent. While its solubility in water is limited, it dissolves readily in organic solvents like ethanol, benzene, and chloroform. This compound serves as an intermediate used in the synthesis of a variety of organic substances, including dyes and agrochemicals. Moreover, it finds extensive applications as an antioxidant in materials such as lubricants, plastics, and rubber, where it provides protections against degradation caused by heat, oxygen, and other elements. 3,5-Dimethylaniline is as a reagent in dye production and is known to undergo polymerization when exposed to cerium(IV) sulfate, acting as an oxidant.


3,5-Dimethylaniline (CAS 108-69-0) References

  1. 2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.  |  Manley, PJ., et al. 2003. Bioorg Med Chem Lett. 13: 1673-7. PMID: 12729639
  2. Identification of adducts formed by reaction of N-acetoxy-3,5-dimethylaniline with DNA.  |  Cui, L., et al. 2007. Chem Res Toxicol. 20: 1730-6. PMID: 18020398
  3. Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry.  |  Strife, RJ., et al. 2009. J Chromatogr A. 1216: 6970-3. PMID: 19733358
  4. Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species.  |  Chao, MW., et al. 2012. Toxicol Sci. 130: 48-59. PMID: 22831970
  5. Intracellular generation of ROS by 3,5-dimethylaminophenol: persistence, cellular response, and impact of molecular toxicity.  |  Chao, MW., et al. 2014. Toxicol Sci. 141: 300-13. PMID: 24973092
  6. Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds.  |  Erkekoglu, P., et al. 2014. Food Chem Toxicol. 72: 98-110. PMID: 25014158
  7. Protective effects of ascorbic acid against the genetic and epigenetic alterations induced by 3,5-dimethylaminophenol in AA8 cells.  |  Chao, MW., et al. 2015. J Appl Toxicol. 35: 466-77. PMID: 25178734
  8. Ultraviolet relaxation dynamics of aniline, N, N-dimethylaniline and 3,5-dimethylaniline at 250 nm.  |  Thompson, JO., et al. 2015. J Chem Phys. 142: 114309. PMID: 25796251
  9. Anti-cancer effects of 3,5-dimethylaminophenol in A549 lung cancer cells.  |  Lin, PY., et al. 2018. PLoS One. 13: e0205249. PMID: 30307971
  10. In Vitro and In Vivo Analysis of the Effects of 3,5-DMA and Its Metabolites in Neural Oxidative Stress and Neurodevelopmental Toxicity.  |  Chao, MW., et al. 2019. Toxicol Sci. 168: 405-419. PMID: 30590852
  11. Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells.  |  Erkekoglu, P., et al. 2019. Arh Hig Rada Toksikol. 70: 18-29. PMID: 30956221
  12. Synthesis of α,δ-Disubstituted Tetraphosphates and Terminally-Functionalized Nucleoside Pentaphosphates.  |  Shepard, SM., et al. 2021. J Am Chem Soc. 143: 463-470. PMID: 33375782
  13. Differences in Pharmacokinetics and Haematotoxicities of Aniline and Its Dimethyl Derivatives Orally Administered in Rats.  |  Miura, T., et al. 2021. Biol Pharm Bull. 44: 1775-1780. PMID: 34433705

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,5-Dimethylaniline, 100 g

sc-238696
100 g
$35.00