3,5-Diiodothyropropionic acid (CAS 1158-10-7)
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3,5-Diiodothyropropionic acid is a compound that functions as a thyroid hormone analog in experimental applications. It acts by binding to thyroid hormone receptors and modulating gene expression, thereby influencing cellular metabolism and growth. 3,5-Diiodothyropropionic acid exerts its mode of action by interacting with nuclear receptors, leading to the regulation of target genes involved in various physiological processes. Through its molecular interactions, 3,5-Diiodothyropropionic acid can influence the transcription of genes related to metabolism, development, and homeostasis. Its role in experimental research involves understanding the molecular mechanisms underlying thyroid hormone signaling and its impact on cellular function. This compound may serve useful for investigating the specific effects of thyroid hormone analogs on gene expression and cellular processes, contributing to a deeper understanding of thyroid hormone function at the molecular level.
3,5-Diiodothyropropionic acid (CAS 1158-10-7) References
- Prevention of abnormal sarcoplasmic reticulum calcium transport and protein expression in post-infarction heart failure using 3, 5-diiodothyropropionic acid (DITPA). | Pennock, GD., et al. 2000. J Mol Cell Cardiol. 32: 1939-53. PMID: 11040100
- Clinical and experimental studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analogue, in heart failure. | Morkin, E., et al. 2002. Thyroid. 12: 527-33. PMID: 12165118
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- DITPA stimulates arteriolar growth and modifies myocardial postinfarction remodeling. | Zheng, W., et al. 2004. Am J Physiol Heart Circ Physiol. 286: H1994-2000. PMID: 15072976
- Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects. | Morkin, E., et al. 2004. J Mol Cell Cardiol. 37: 1137-46. PMID: 15572044
- Proangiogenesis action of the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) is initiated at the cell surface and is integrin mediated. | Mousa, SA., et al. 2006. Endocrinology. 147: 1602-7. PMID: 16384862
- Thyroid hormones and 3,5-diiodothyropropionic acid: new keys for new locks. | Yen, PM. 2006. Endocrinology. 147: 1598-601. PMID: 16543378
- A phosphorimager-based filter binding thyroid hormone receptor competition assay for chemical screening. | Chapo, J., et al. 2007. J Pharmacol Toxicol Methods. 56: 28-33. PMID: 17276701
- Regulation of gene expression in rats with heart failure treated with the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) and the combination of DITPA and captopril. | Maitra, N., et al. 2007. J Cardiovasc Pharmacol. 50: 526-34. PMID: 18030062
- Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function. | Liu, Y., et al. 2009. Am J Physiol Heart Circ Physiol. 296: H1551-7. PMID: 19286941
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- Combination treatment with captopril and the thyroid hormone analogue 3,5-diiodothyropropionic acid. A new approach to improving left ventricular performance in heart failure. | Pennock, GD., et al. 1993. Circulation. 88: 1289-98. PMID: 8353891
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,5-Diiodothyropropionic acid, 50 mg | sc-256593 | 50 mg | $184.00 |