Molecular structure of 3,5-Diiodo-L-thyronine, CAS Number: 1041-01-6
3,5-Diiodo-L-thyronine (CAS 1041-01-6)
See product citations (2)
Alternate Names:
O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine; 3-[4-(p-Hydroxyphenoxy)-3,5-diiodophenyl]-L-alanine; L-T2
Application:
3,5-Diiodo-L-thyronine is an iodinated thyronine hormone that regulates activity
CAS Number:
1041-01-6
Purity:
≥95%
Molecular Weight:
525.08
Molecular Formula:
C15H13I2NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3,5-Diiodo-L-thyronine is a chemical analog of thyroid hormones, often utilized in metabolic research due to its influence on basal metabolic rate. Studies involving this compound largely focus on its effect on mitochondrial activity, particularly how it modulates oxidative metabolism. Researchers employ 3,5-Diiodo-L-thyronine to understand the regulation of lipid and carbohydrate metabolism at the cellular level. It serves as a tool in exploring the mechanisms of energy expenditure and has been instrumental in studies investigating the biochemical pathways involved in energy balance. Additionally, its role in the modulation of gene expression related to metabolism is of interest, as it provides insights into how thyroid hormone derivatives can alter the transcription of genes involved in metabolic processes.
3,5-Diiodo-L-thyronine (CAS 1041-01-6) References
- 3,5-Diiodo-L-thyronine administration to hypothyroid rats rapidly enhances fatty acid oxidation rate and bioenergetic parameters in liver cells. | Cavallo, A., et al. 2013. PLoS One. 8: e52328. PMID: 23308110
- 3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats. | Shang, G., et al. 2013. Biochim Biophys Acta. 1832: 674-84. PMID: 23416120
- Hippocampal gene expression of deiodinases 2 and 3 and effects of 3,5-diiodo-L-thyronine T2 in mouse depression paradigms. | Markova, N., et al. 2013. Biomed Res Int. 2013: 565218. PMID: 24386638
- 3,5-diiodo-L-thyronine modifies the lipid droplet composition in a model of hepatosteatosis. | Grasselli, E., et al. 2014. Cell Physiol Biochem. 33: 344-56. PMID: 24525903
- 3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. | Jonas, W., et al. 2015. Endocrinology. 156: 389-99. PMID: 25322465
- 3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects? | Hernandez, A. 2015. Endocrinology. 156: 5-7. PMID: 25526549
- Proteomic approaches for the study of tissue specific effects of 3,5,3'-triiodo-L-thyronine and 3,5-diiodo-L-thyronine in conditions of altered energy metabolism. | Silvestri, E., et al. 2014. Front Physiol. 5: 491. PMID: 25566089
- 3,5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats. | Lombardi, A., et al. 2015. PLoS One. 10: e0116498. PMID: 25658324
- 3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. | Vatner, DF., et al. 2015. PLoS One. 10: e0140837. PMID: 26485433
- 3,5-diiodo-L-thyronine: A Possible Pharmacological Agent? | Coppola, M., et al. 2016. Curr Drug Deliv. 13: 330-8. PMID: 26593437
- Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats stimulates bioenergetic parameters in liver mitochondria. | Cavallo, A., et al. 2016. J Bioenerg Biomembr. 48: 521-529. PMID: 27854029
- 3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice. | Moreno, M., et al. 2016. Front Physiol. 7: 545. PMID: 27909409
- Direct and rapid effects of 3,5-diiodo-L-thyronine (T2). | Moreno, M., et al. 2017. Mol Cell Endocrinol. 458: 121-126. PMID: 28192176
- Both 3,5-diiodo-L-thyronine (T2) and T3 modulate glucose-induced insulin secretion. | Fallahi, P., et al. 2017. J Biol Regul Homeost Agents. 31: 503-508. PMID: 28685559
- Both 3,5-Diiodo-L-Thyronine and 3,5,3'-Triiodo-L-Thyronine Prevent Short-term Hepatic Lipid Accumulation via Distinct Mechanisms in Rats Being Fed a High-Fat Diet. | Senese, R., et al. 2017. Front Physiol. 8: 706. PMID: 28959215
Inhibitor of:
TRβ1.Activator of:
1810020O05Rik, c-Erb-A α, c-Erb-A β-2, CLC-1, CTL5, FTSJ1, Glycogenin-2, LOC646066, MC5R, METT11D1, MUP16, Obox5, Olr1218, OTP, SLC26A10, SLC43A1, SLC4A8, TMEM167, and TR α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,5-Diiodo-L-thyronine, 1 g | sc-216601 | 1 g | $270.00 | |||
3,5-Diiodo-L-thyronine, 5 g | sc-216601A | 5 g | $562.00 | |||
3,5-Diiodo-L-thyronine, 10 g | sc-216601B | 10 g | $938.00 | |||
3,5-Diiodo-L-thyronine, 25 g | sc-216601C | 25 g | $1408.00 | |||
3,5-Diiodo-L-thyronine, 100 g | sc-216601D | 100 g | $2673.00 |