Date published: 2026-4-29

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3,5-Difluoropyridine (CAS 71902-33-5)

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CAS Number:
71902-33-5
Molecular Weight:
115.08
Molecular Formula:
C5H3F2N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,5-Difluoropyridine, a heterocyclic compound, plays a vital role in scientific research as a building block for the synthesis of fluorinated compounds. Its versatile nature has led to its application in the synthesis of various agrochemicals, organic compounds, fluorinated polymers, and other materials. Additionally, its significance extends to the synthesis of fluorinated dyes and other compounds.


3,5-Difluoropyridine (CAS 71902-33-5) References

  1. Microwave spectroscopic investigation and structural determination of the Ar-difluoropyridine van der Waals complexes.  |  Sun, M., et al. 2014. J Phys Chem A. 118: 8730-6. PMID: 25146691
  2. Directly Diphenylborane-Fused Porphyrins.  |  Fujimoto, K., et al. 2016. Angew Chem Int Ed Engl. 55: 3196-9. PMID: 26821874
  3. Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes.  |  Roesner, S. and Buchwald, SL. 2016. Angew Chem Int Ed Engl. 55: 10463-7. PMID: 27456275
  4. The formation of all-cis-(multi)fluorinated piperidines by a dearomatization-hydrogenation process.  |  Nairoukh, Z., et al. 2019. Nat Chem. 11: 264-270. PMID: 30664720
  5. Fluorinated pyridine derivatives: Part 1. The synthesis of some mono- and bis-quaternary pyridine salts of potential use in the treatment of nerve agent poisoning  |  Christopher M. Timperley, Mike Bird, Suzannah C. Heard, Stuart Notman, Robert W. Read, John E.H. Tattersall, Simon R. Turner. 2005. Journal of Fluorine Chemistry. 126: 1160-1165.
  6. Investigation of structural trends in difluoropyridine rings using chirped-pulse Fourier transform microwave spectroscopy and ab initio calculations  |  Cody W. van Dijk, Ming Sun, Jennifer van Wijngaarden. 2012. Journal of Molecular Spectroscopy. 280: 34-41.
  7. Microwave spectrum and structure of the 3,5-difluoropyridine⋯CO2 van der Waals complex  |  Christopher T. Dewberry a, Ryan D. Cornelius b, Rebecca B. Mackenzie c, C.J. Smith c, Michael A. Dvorak b, Kenneth R. Leopold c. 2016. Journal of Molecular Spectroscopy. 328: 67-72.
  8. Design, synthesis, characterization, and anti-tubercular activity of novel ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues: Molecular target identification and molecular docking studies  |  Priyanka Mundhe a, Saqib Kidwai b, Surbhi Mahender Saini a, Harshada Rambaboo Singh a, Ramandeep Singh b, Sandeep Chandrashekharappa a. 2023. Journal of Molecular Structure. 1284.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,5-Difluoropyridine, 1 g

sc-232107
1 g
$45.00