Molecular structure of 3,5-Dichloro-4-methoxybenzaldehyde, CAS Number: 41727-58-6
3,5-Dichloro-4-methoxybenzaldehyde (CAS 41727-58-6)
CAS Number:
41727-58-6
Molecular Weight:
205.04
Molecular Formula:
C8H6Cl2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Stat3 Inhibitor VIII, 5,15-DPP is a cell-permeable porphyrin compound that binds Stat3 (STAT3, KD = 880 nM by SPR) and prevents Stat3 SH2 domain-mediated ligand binding (IC50 = 280 nM) and dimerization (~60% inhibition at 50 muM in HEK293), while exhibiting much reduced activity against STAT1 ligand binding (IC50 = 10 muM) and no activity againt Grb2 ligand binding even at concentrations as high as 20 muM. Stat3 Inhibitor VIII, 5,15-DPP pre-treatment (50 muM) of MDA-MB-468 cultures is shown to greatly inhibit IL-6-induced Stat3, but not STAT1/5a/5b, nuclear translocation (by >90%) and nuclear Stat3 c-myc promoter binding activity, resulting in a more than 90% reduction in cellular c-myc protein level.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,5-Dichloro-4-methoxybenzaldehyde, 500 mg | sc-313679 | 500 mg | $260.00 |