![3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-methylbenzamide - chemical structure image](https://media.scbt.com/product/3-5-chloromethyl-1-2-4-oxadiazol-3-yl-4-methoxy-n-methylbenzamide-structure_22_70_b_227039.jpg)
![3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-methylbenzamide - chemical structure image](https://media.scbt.com/product/3-5-chloromethyl-1-2-4-oxadiazol-3-yl-4-methoxy-n-methylbenzamide-structure_22_70_t_227039.jpg "Molecular structure of 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-methylbenzamide")
Molecular structure of 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-methylbenzamide
3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-methylbenzamide
Molecular Weight:
281.7
Molecular Formula:
C12H12ClN3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ZM-447439 is a selective inhibitor of aurora kinases ARK-1 (A) (IC50=1000 nM), ARK-2 (B) (IC50= 50 nM) and ARK-3 (C), that can induce growth arrest, inhibit histone H3 phosphorylation and effectively activate apoptosis. The compound specifically interacts at the ATP-binding site and at the adjacent cleft, found only in aurora kinases. In the presence of Z-M447439, chromosome alignment, segregation, and cytokinesis during mitosis are unsuccessful. Studies show that ZM-447439 can override the spindle assembly checkpoint and accelerate meiosis I in mouse oocytes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-methylbenzamide, 500 mg | sc-310751 | 500 mg | $450.00 |