Date published: 2025-12-7

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3,5,5-Trimethylhexanoyl chloride (CAS 36727-29-4)

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CAS Number:
36727-29-4
Molecular Weight:
176.68
Molecular Formula:
C9H17ClO
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,5,5-Trimethylhexanoyl chloride is a chemical compound that functions as an acylating agent in organic synthesis. Its mechanism of action involves the acylation of various nucleophiles, such as alcohols, amines, and thiols, to form esters, amides, and thioesters, respectively. This compound is utilized in the modification of organic molecules to introduce the 3,5,5-trimethylhexanoyl group, which can alter the physicochemical properties of the target compounds. In the experimental context, 3,5,5-trimethylhexanoyl chloride serves as a reagent for the synthesis of diverse organic compounds, allowing for the introduction of specific functional groups and the generation of novel chemical entities. Its mode of action involves the activation of the carbonyl group, facilitating the formation of covalent bonds with nucleophilic substrates. This chemical plays a role in the development of new materials and compounds for various research applications, contributing to the advancement of organic chemistry and related fields.


3,5,5-Trimethylhexanoyl chloride (CAS 36727-29-4) References

  1. The lipophilic iron compound TMH-ferrocene [(3,5,5-trimethylhexanoyl)ferrocene] increases iron concentrations, neuronal L-ferritin, and heme oxygenase in brains of BALB/c mice.  |  Malecki, EA., et al. 2002. Biol Trace Elem Res. 86: 73-84. PMID: 12002662
  2. Iron overload of the bone marrow by trimethylhexanoyl-ferrocene in rats.  |  Braumann, A., et al. 1992. Acta Anat (Basel). 144: 285-95. PMID: 1414192
  3. Iron overload of the liver by trimethylhexanoylferrocene in rats.  |  Düllmann, J., et al. 1992. Acta Anat (Basel). 143: 96-108. PMID: 1598822
  4. Calorimetric study of peroxycarboxylic ester synthesis.  |  Fritzsche, L. and Knorr, A. 2009. J Hazard Mater. 163: 1403-7. PMID: 18722058
  5. Synthesis, aggregation behavior and interfacial activity of branched alkylbenzenesulfonate gemini surfactants.  |  Zhang, Q., et al. 2011. J Colloid Interface Sci. 362: 406-14. PMID: 21764066
  6. Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction.  |  Kulshreshtha, A. and Piplani, P. 2016. Eur J Med Chem. 122: 557-573. PMID: 27448914
  7. Dietary lipophilic iron accelerates regional brain iron-load in C57BL6 mice.  |  Peters, DG., et al. 2018. Brain Struct Funct. 223: 1519-1536. PMID: 29168009
  8. Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice.  |  Peters, DG., et al. 2018. Metallomics. 10: 426-443. PMID: 29424844
  9. Tuning water adsorption, stability, and phase in Fe-MIL-101 and Fe-MIL-88 analogs with amide functionalization.  |  Kuznicki, A., et al. 2021. Chem Commun (Camb). 57: 8312-8315. PMID: 34319317
  10. Metabolism of iron from (3,5,5-trimethylhexanoyl)ferrocene in rats. A dietary model for severe iron overload.  |  Nielsen, P. and Heinrich, HC. 1993. Biochem Pharmacol. 45: 385-91. PMID: 8435091
  11. Thiol-ene coupling: An efficient tool for the synthesis of new biobased aliphatic amines for epoxy curing  |  Cornille, A., Froidevaux, V., Negrell, C., Caillol, S., & Boutevin, B. 2014. Polymer. 55(22): 5561-5570.
  12. A study of cyclic carbonate aminolysis at room temperature: effect of cyclic carbonate structures and solvents on polyhydroxyurethane synthesis  |  Cornille, A., Blain, M., Auvergne, R., Andrioletti, B., Boutevin, B., & Caillol, S. 2017. Polymer Chemistry. 8(3): 592-604.
  13. Continuous production of 3, 5, 5-trimethylhexanoyl chloride and CFD simulations of single-phase flow in an advanced-flow reactor  |  Wang, N., Jin, Y., Huang, T., Zhou, J., Zhang, Y., & Li, N. 2022. Journal of the Taiwan Institute of Chemical Engineers. 138: 104465.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,5,5-Trimethylhexanoyl chloride, 10 g

sc-232149
10 g
$29.00

3,5,5-Trimethylhexanoyl chloride, 50 g

sc-232149A
50 g
$143.00

3,5,5-Trimethylhexanoyl chloride, 100 g

sc-232149B
100 g
$265.00