Molecular structure of 3,5,4′-Trimethoxystilbene, CAS Number: 22255-22-7
3,5,4′-Trimethoxystilbene (CAS 22255-22-7)
Application:
3,5,4′-Trimethoxystilbene is an antiangiogenic agent that is shown to inhibit endothelial cell proliferation
CAS Number:
22255-22-7
Purity:
≥97%
Molecular Weight:
270.3
Molecular Formula:
C17H18O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3,5,4'-Trimethoxystilbene, an antiangiogenic agent and permethylated derivative of Resveratrol (sc-200808), has been shown to inhibit endothelial cell proliferation, and cause microtubule disassembly and tubulin depolymerization. It has been reported that this compound induces apoptosis via modulation of mitochondrial functions regulated by reactive oxygen species. Further studies note that 3,5,4'-Trimethoxystilbene causes reactive oxygen species generation in the early stages of the induced apoptosis, preceding cytochrome-c release, caspase activation, and DNA fragmentation.
3,5,4′-Trimethoxystilbene (CAS 22255-22-7) References
- Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells. | Matsuda, H., et al. 2004. Bioorg Med Chem. 12: 4871-6. PMID: 15336266
- Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. | de Medina, P., et al. 2005. J Med Chem. 48: 287-91. PMID: 15634023
- Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. | Belleri, M., et al. 2005. Mol Pharmacol. 67: 1451-9. PMID: 15703378
- Antitumor activity of 3,5,4'-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice. | Pan, MH., et al. 2008. Mol Carcinog. 47: 184-96. PMID: 18085528
- Local inhibition of angiogenesis results in an atrophic non-union in a rat osteotomy model. | Fassbender, M., et al. 2011. Eur Cell Mater. 22: 1-11. PMID: 21732278
- [Trimethoxystilbene and its effects on the proliferation and apoptosis of PASMCs]. | Wang, X., et al. 2012. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 37: 390-9. PMID: 22561559
- Scavenging of hydroxyl radical by resveratrol and related natural stilbenes after hydrogen peroxide attack on DNA. | Rossi, M., et al. 2013. Chem Biol Interact. 206: 175-85. PMID: 24075811
- Effect of tannic acid, resveratrol and its derivatives, on oxidative damage and apoptosis in human neutrophils. | Zielińska-Przyjemska, M., et al. 2015. Food Chem Toxicol. 84: 37-46. PMID: 26231140
- The effect of resveratrol, its naturally occurring derivatives and tannic acid on the induction of cell cycle arrest and apoptosis in rat C6 and human T98G glioma cell lines. | Zielińska-Przyjemska, M., et al. 2017. Toxicol In Vitro. 43: 69-75. PMID: 28595835
- Natural products hybrids: 3,5,4'-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells. | Hassan, AHE., et al. 2019. Eur J Med Chem. 161: 559-580. PMID: 30396104
- High-yield production of multiple O-methylated phenylpropanoids by the engineered Escherichia coli-Streptomyces cocultivation system. | Cui, H., et al. 2019. Microb Cell Fact. 18: 67. PMID: 30971246
- Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors. | Guo, K., et al. 2021. Front Oncol. 11: 644134. PMID: 33937049
- Trans-3, 5, 4'-trimethoxystilbene restrains non-small-cell lung carcinoma progression via suppressing M2 polarization through inhibition of m6A modified circPACRGL-mediated Hippo signaling. | Liu, X., et al. 2024. Phytomedicine. 126: 155436. PMID: 38394728
Inhibitor of:
Angiogenesis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,5,4'-Trimethoxystilbene, 100 mg | sc-201450 | 100 mg | $65.00 | |||
3,5,4'-Trimethoxystilbene, 500 mg | sc-201450A | 500 mg | $161.00 |