Molecular structure of 3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide, CAS Number: 615264-62-5
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide (CAS 615264-62-5)
Alternate Names:
N-[3-(3,4-dihydroxyphenyl)-1-oxopropyl]-L-aspartic acid, bis(phenylmethyl) ester
Application:
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide is a cholesterol acyltransferase-1 and -2 inhibitor
CAS Number:
615264-62-5
Molecular Weight:
477.50
Molecular Formula:
C27H27NO7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from long chain fatty acyl-coenzyme A and cholesterol, and may play a role in the development of atherosclerosis (1,2). This chemical inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively (3) and also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 µM (3).
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide (CAS 615264-62-5) References
- Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. | Lee, RG., et al. 2000. J Lipid Res. 41: 1991-2001. PMID: 11108732
- Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. | Rudel, LL., et al. 2001. Curr Opin Lipidol. 12: 121-7. PMID: 11264983
- Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. | Lee, S., et al. 2004. Bioorg Med Chem Lett. 14: 4677-81. PMID: 15324887
Inhibitor of:
ACAT-1, and ACAT-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide, 5 mg | sc-223562 | 5 mg | $43.00 | |||
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide, 10 mg | sc-223562A | 10 mg | $108.00 | |||
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide, 50 mg | sc-223562B | 50 mg | $343.00 | |||
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide, 100 mg | sc-223562C | 100 mg | $600.00 |