Date published: 2025-9-25

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3,4-Difluorophenyl isocyanate (CAS 42601-04-7)

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Alternate Names:
Isocyanic Acid 3,4-Difluorophenyl Ester
CAS Number:
42601-04-7
Molecular Weight:
155.10
Molecular Formula:
C7H3F2NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,4-Difluorophenyl isocyanate (DFPI) is a remarkable and versatile chemical compound with broad applications in various fields. As a colorless, water-soluble, and volatile liquid, 3,4-Difluorophenyl isocyanate serves as a valuable reagent, catalyst, and intermediate in diverse chemical reactions. The compound has garnered significant attention in scientific and industrial circles due to its unique properties and potential for multifaceted applications. The mechanism of action of 3,4-Difluorophenyl isocyanate is contingent upon the specific reaction it engages in. Generally, this compound exhibits high reactivity, forming diverse covalent bonds with other molecules. In organic syntheses, it serves as a nucleophile, engaging in electrophilic substrates to create new covalent bonds. In catalytic reactions, 3,4-Difluorophenyl isocyanate acts as a Lewis acid, facilitating the formation of covalent bonds between reactants.


3,4-Difluorophenyl isocyanate (CAS 42601-04-7) References

  1. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.  |  Wen, W., et al. 2013. Bioorg Med Chem Lett. 23: 4562-6. PMID: 23838260
  2. Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity.  |  Torres-Gómez, H., et al. 2021. Int J Mol Sci. 22: PMID: 34073622

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,4-Difluorophenyl isocyanate, 2 g

sc-232000
2 g
$51.00