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3,4-Dephostatin is a PTP (protein tyrosine phosphatase) inhibitor that enhances growth factor-induced differentiation in PC12 cells possibly by sustaining MAP kinase activity. 3,4-Dephostatin can also be used as a protein S-nitrosylating agent and exhibits greater stability than Dephostatin. 3,4-Dephostatin is an inhibitor of SH-PTP1 and PTP1B.
Fujiwara, S., et al. 1997. Biochem. Biophys. Res. Commun. 238, 213. Umezawa, K. 1997. Adv. Enz. Regul. 37, 393. Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
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