3,4-Dephostatin MF: C7H8N2O3
MW: 168.15
A protein tyrosine phosphatase inhibitor.

3,4-Dephostatin

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Synonym: 3,4-Dihydroxy-N-methyl-N-nitrosoaniline
Application: A protein tyrosine phosphatase inhibitor
Purity: ≥98%
Molecular Weight: 168.15
Molecular Formula: C7H8N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).

3,4-Dephostatin is a PTP (protein tyrosine phosphatase) inhibitor that enhances growth factor-induced differentiation in PC12 cells possibly by sustaining MAP kinase activity. 3,4-Dephostatin can also be used as a protein S-nitrosylating agent and exhibits greater stability than Dephostatin. 3,4-Dephostatin is an inhibitor of SH-PTP1 and PTP1B.


References

Fujiwara, S., et al. 1997. Biochem. Biophys. Res. Commun. 238, 213. Umezawa, K. 1997. Adv. Enz. Regul. 37, 393. Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (18 mg/mL). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
125.55° C (Predicted)
Boiling Point :
449.47° C at 760 mmHg (Predicted)
Density :
1.37 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
protein tyrosine phosphatase: IC50 = 18 µM
Ki Data :
hydrolysis of p-nitrophenyl phosphate: Ki= 1.6 µM
pK Values :
pKa: 9.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5353329
MDL Number :
MFCD01076450
SMILES :
CN(C1=CC(=O)C(=O)C=C1)NO

Download SDS (MSDS)

Certificate of Analysis

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