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Tranylcypromine is an irreversible inhibitor of monoamine oxidase (MAO), and an inhibitor of CYP2A6 (Ki= 0.08 muM) and histone demethylase BHC110/LSD1. The inhibitor targets MAO-A and MAO-B and has been used as a chemical scaffold to design new demethylase inhibitors. Studies suggest that tranylcypromine can increase both brain trace amines and GABA(B)-receptors, and regulate phospholipid metabolism. Tranylcypromine may act to increase Histone H3 lysine 4 (H3K4) methylation and transcriptional derepression of Egr1 and Oct4 in P19 embryonal carcinoma cells (sc-24760). Studies indicate that it is an effective inhibitor of histone demethylation and can antagonize the effects of phenylephrine.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[4-(Benzyloxy)phenoxy]piperidine, 500 mg | sc-310732 | 500 mg | $294.00 |