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Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. It exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, overexpressed in many malignancies. Additionally, it is an inhibitor of FOXM1.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,4,7-Trimethyl-1H-indole-2-carboxylic acid, 500 mg | sc-313653 | 500 mg | $260.00 |