Molecular structure of 3,4,5,3′,4′,5′-Hexabromobiphenyl, CAS Number: 60044-26-0
3,4,5,3′,4′,5′-Hexabromobiphenyl (CAS 60044-26-0)
Alternate Names:
3,3′,4,4′,5,5′-Hexabromobiphenyl; 3,3′,4,4′,5,5′-Hexabromo-1,1′-Biphenyl; PBB 169
CAS Number:
60044-26-0
Molecular Weight:
627.58
Molecular Formula:
C12H4Br6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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3,3′,4,4′,5,5′-Hexabromobiphenyl, a type of brominated flame retardant, plays a role in the manufacturing of polymers and textiles. Studies have revealed that this compound can impede the synthesis of uridine in mammalian cells. This inhibition may arise from its capacity to form a complex with the enzyme uridine phosphorylase, or it could be an indirect consequence of its impact on cellular energy metabolism.
3,4,5,3′,4′,5′-Hexabromobiphenyl (CAS 60044-26-0) References
- Polychlorinated and polybrominated biphenyl congeners and retinoid levels in rat tissues: structure-activity relationships. | Chen, LC., et al. 1992. Toxicol Appl Pharmacol. 114: 47-55. PMID: 1316647
- Increased thyroxine turnover after 3,3',4,4',5,5'-hexabromobiphenyl injection and lack of effect on peripheral triiodothyronine production. | Spear, PA., et al. 1990. Can J Physiol Pharmacol. 68: 1079-84. PMID: 2167764
- 2,4,5,3',4',5'-Hexabromobiphenyl is both a 3-methylcholanthrene-and a phenobarbital-type inducer of microsomal drug metabolizing enzymes. | Dannan, GA., et al. 1978. Biochem Biophys Res Commun. 85: 450-8. PMID: 217380
- The induction of alkoxyresorufin metabolism: a potential indicator of environmental contamination. | Lubet, RA., et al. 1990. Arch Environ Contam Toxicol. 19: 157-63. PMID: 2322016
- Vitamin A metabolism in rats chronically treated with 3,3',4,4',5,5'-hexabromobiphenyl. | Jensen, RK., et al. 1987. Biochim Biophys Acta. 926: 310-20. PMID: 2825801
- Increased retinoic acid metabolism following 3,3',4,4',5,5'-hexabromobiphenyl injection. | Spear, PA., et al. 1988. Can J Physiol Pharmacol. 66: 1181-6. PMID: 2851384
- Sequential study on the synergistic effects of 2,2',4,4',5,5'-hexabromobiphenyl and 3,3',4,4',5,5'-hexabromobiphenyl on hepatic tumor promotion. | Jensen, RK. and Sleight, SD. 1986. Carcinogenesis. 7: 1771-4. PMID: 2875811
- Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of the structure-activity relationship. | Poland, A. and Glover, E. 1977. Mol Pharmacol. 13: 924-38. PMID: 408602
- Liver microsomal enzyme induction and toxicity studies with 2,4,5,3',4'-pentabromobiphenyl. | Dannan, GA., et al. 1982. Toxicol Appl Pharmacol. 64: 187-203. PMID: 6289491
- Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability. | Jensen, RK., et al. 1983. Toxicol Appl Pharmacol. 71: 163-76. PMID: 6314605
- Effects of fasting and 3,3',4,4',5,5'-hexabromobiphenyl on plasma transport of thyroxine and retinol: fasting reverses elevation of retinol. | Spear, PA., et al. 1994. J Toxicol Environ Health. 42: 173-83. PMID: 8207753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,4,5,3′,4′,5′-Hexabromobiphenyl, 25 mg | sc-489616 | 25 mg | $5728.00 |