Date published: 2026-4-26

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3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propionic acid

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Molecular Weight:
264.32
Molecular Formula:
C14H20N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propionic acid, 500 mg

sc-310725
500 mg
$260.00