3,3prime-Dithiodipropionic acid di(N-hydroxysuccinimide ester) CAS: 57757-57-0
MF: C14H16N2O8S2
MW: 404.42
A cleavable disulfide linkage-containing homobifunctional cross-linking reagent.

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (CAS 57757-57-0)

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester), CAS 57757-57-0 is rated 5.0 out of 5 by 1.
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Alternate Names: DTSP; Lomant's reagent
Application: 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) is a cleavable disulfide linkage-containing homobifunctional cross-linking reagent
CAS Number: 57757-57-0
Purity: ≥99%
Molecular Weight: 404.42
Molecular Formula: C14H16N2O8S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester) is a cleavable disulfide linkage-containing homobifunctional cross-linking reagent. Has typical molecular coupling to primary amines via buffered (pH 7.5) amide bonds.


References

1. Lomant, A.J. and Fairbanks, G., Chemical probes of extended biological structures: synthesis and properties of the cleavable protein cross-linking reagent [35S]dithiobis(succinimidyl propionate). J. Mol. Biol. 104, 243-261, (1976) 2. Darder M., et al., Dithiobissuccinimidyl propionate as an anchor for assembling peroxidases at electrodes surfaces and its application in a H2O2 biosensor. Anal. Chem. 71, 5530, (1999)

Appearance :
Powder
Physical State :
Solid
Solubility :
chloroform: 50 mg/mL: DMF: soluble: acetone: soluble
Storage :
Store at -20° C
Melting Point :
128° C
Boiling Point :
560.14° C at 760 mmHg (Predicted)
Density :
1.58 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
93313
MDL Number :
MFCD00042045
EC Number :
260-931-5
Beilstein Registry :
1518074
SMILES :
C1CC(=O)N(C1=O)OC(=O)CCSSCCC(=O)ON2C(=O)CCC2=O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Jackson Jackson, V. et al. (PubMed 3620449) reinvestigated studies using 3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester) reagent to cross-link newly synthesized density-labeled histones into octameric complexes to determine the nature of histone deposition. Studies indicate that density-labeled, newly synthesized histones form hybrid octameric structures composed of both new and old histones. -SCBT Publication Review
Date published: 2015-01-23
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