Molecular structure of 3,3′,5,5′-Tetraiodothyroacetic acid, CAS Number: 67-30-1
3,3′,5,5′-Tetraiodothyroacetic acid (CAS 67-30-1)
See product citations (3)
Alternate Names:
4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid; Tetrac
CAS Number:
67-30-1
Purity:
≥98%
Molecular Weight:
747.83
Molecular Formula:
C14H8O4I4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Tetraiodothyroacetic acid (Tetrac) is a derivative of L-thyroxine (T4) and functions as a thyrointegrin receptor antagonist. By binding to the cell surface receptor for thyroid hormone on integrin αvβ3, Tetrac effectively inhibits the actions of T4 and 3,5,3′-triiodo-L-thyronine (T3). Notably, Tetrac exhibits significant anti-angiogenic and anti-tumor activities.
3,3′,5,5′-Tetraiodothyroacetic acid (CAS 67-30-1) References
- Inhibition of the activity of the native gamma-aminobutyric acid A receptor by metabolites of thyroid hormones: correlations with molecular modeling studies. | Martin, JV., et al. 2004. Brain Res. 1004: 98-107. PMID: 15033424
- Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution. | Neumann, P., et al. 2005. Acta Crystallogr D Biol Crystallogr. 61: 1313-9. PMID: 16204882
- Protective effect of 3,5,3'-triiodothyroacetic and 3,5,3',5'-tetraiodothyroacetic acids on serum albumin fibrillation. | Cortez, LM., et al. 2009. Eur Biophys J. 38: 857-63. PMID: 19381627
- Characterization of iodothyronine sulfotransferase activity in the cytosol of Rana catesbeiana tadpole tissues. | Rahman, FB. and Yamauchi, K. 2010. Gen Comp Endocrinol. 166: 396-403. PMID: 20036241
- Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro. | Ishibashi, H., et al. 2013. Brain Res. 1490: 1-8. PMID: 23103412
- Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8. | Horn, S., et al. 2013. Endocrinology. 154: 968-79. PMID: 23307789
- Inherited defects of thyroid hormone-cell-membrane transport: review of recent findings. | Fu, J., et al. 2013. Curr Opin Endocrinol Diabetes Obes. 20: 434-40. PMID: 23974772
- 64Cu-Labeled tetraiodothyroacetic acid-conjugated liposomes for PET imaging of tumor angiogenesis. | Kang, CM., et al. 2013. Nucl Med Biol. 40: 1018-24. PMID: 24035550
- Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy. | Fernando, R., et al. 2017. J Clin Endocrinol Metab. 102: 776-785. PMID: 27768856
- Combined Treatment of Heteronemin and Tetrac Induces Antiproliferation in Oral Cancer Cells. | Huang, CH., et al. 2020. Mar Drugs. 18: PMID: 32630719
- Nano-Strategies Targeting the Integrin αvβ3 Network for Cancer Therapy. | Cheng, TM., et al. 2021. Cells. 10: PMID: 34359854
- Uptake of 3,3',5,5'-tetraiodothyroacetic acid and 3,3',5'-triiodothyronine in cultured rat anterior pituitary cells and their effects on thyrotropin secretion. | Everts, ME., et al. 1995. Endocrinology. 136: 4454-61. PMID: 7664665
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,3′,5,5′-Tetraiodothyroacetic acid, 25 mg | sc-231969 | 25 mg | $118.00 | |||
3,3′,5,5′-Tetraiodothyroacetic acid, 50 mg | sc-231969A | 50 mg | $159.00 | |||
3,3′,5,5′-Tetraiodothyroacetic acid, 100 mg | sc-231969B | 100 mg | $272.00 | |||
3,3′,5,5′-Tetraiodothyroacetic acid, 250 mg | sc-231969C | 250 mg | $516.00 | |||
3,3′,5,5′-Tetraiodothyroacetic acid, 500 mg | sc-231969D | 500 mg | $924.00 |