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![3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole (CAS 443](https://media.scbt.com/product/3-3-fluoro-5-tetrahydro-4-methoxy-2h-pyran-4-yl-phenoxymethyl-1-4-methylsulfonyl-phenyl-5-phenyl-1h-pyrazole-443919-96-8-structure_40_52_t_405285.jpg "Molecular structure of 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole, CAS Number: 443919-96-8")
3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole (CAS 443919-96-8)
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3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole is a dual inhibitor of Cox-2 (cyclooxygenase-2) and 5-LO (5-lipoxygenase) (IC50 of 50 nM and 3 nM, respectively). 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole is selective for Cox-2 over Cox-1 by greater than 200-fold. Cox-2/5-LO inhibitors are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole exhibits a 45% inhibition of proliferation at 100 μM, and in the LNCaP human carcinoma cell line, a IC50 value of 83 μM.
3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole (CAS 443919-96-8) References
- Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. | Barbey, S., et al. 2002. Bioorg Med Chem Lett. 12: 779-82. PMID: 11859001
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole, 1 mg | sc-205108 | 1 mg | $90.00 | |||
3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole, 5 mg | sc-205108A | 5 mg | $406.00 |