![3,3-Dimethyl-2-methylene-bicyclo[2.2.1]-heptane-1-carboxylic acid (CAS 10309-20-3) - chemical structure image](https://media.scbt.com/product/3-3-dimethyl-2-methylene-bicyclo2-2-1-heptane-1-carboxylic-acid-10309-20-3-structure_22_95_b_229574.jpg)
![Molecular structure of 3,3-Dimethyl-2-methylene-bicyclo[2.2.1]-heptane-1-carboxylic acid, CAS Number: 10309-20-3 3,3-Dimethyl-2-methylene-bicyclo[2.2.1]-heptane-1-carboxylic acid (CAS 10309-20-3) - chemical structure image](https://media.scbt.com/product/3-3-dimethyl-2-methylene-bicyclo2-2-1-heptane-1-carboxylic-acid-10309-20-3-structure_22_95_t_229574.jpg)
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SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). This compound may act to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and Elk-1 phosphorylation, and LTP-dependent gene induction, resulting in rapidly decaying LTP, while being uncompetitive with respect to ATP. SL-327 has also been shown to inhibit ERK1, MEK-3/p38, MEK-4, JNK, and PKC activities when used at higher concentrations.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,3-Dimethyl-2-methylene-bicyclo[2.2.1]-heptane-1-carboxylic acid, 500 mg | sc-313576 | 500 mg | $240.00 |